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Dual specificity phosphatase

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{{STRUCTURE_1ohe| PDB=1ohe | SIZE=400 | SCENE= |right|CAPTION=Human Cdc14B2 core domain complex with peptide (PDB code [[1ohe]]). }}
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__NOTOC__
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'''Dual specificity phosphatase''' (DUSP) is a phosphatase which acts on tyrosine, serine or threonine residues. There are several DUSP enzymes in mammals sharing a common catalytic mechanism. The DUSP include:<br />
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• Slingshot phosphatase<br />
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• Phosphatase of regenerating liver<br />
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• Cdc14<br />
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• Cdc25<br />
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• PTEN<br />
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• Myotubularin<br />
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• MAPK phosphatase see [[MAP kinase phosphatase]]<br />
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==3D structures of dual specificity phosphatase==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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===slingshot phosphatase (SSH)===
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[[2nt2]] – hSSH-2L catalytic domain - human<br />
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===Phosphatase of regenerating liver (RPL)===
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[[1xm2]] – hPRL-1 (mutant)<br />
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[[1zck]], [[1x24]] – rPRL-1 - rat<br />
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[[1zcl]] – rPRL-1 (mutant)<br />
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[[1r6h]], [[1v3a]], [[2mbc]] – hPRL-3 - NMR<br />
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===Cdc14===
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[[1ohc]], [[1ohd]] – hCdc14B2 core domain <br />
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[[1ohe]] – hCdc14B2 core domain + peptide<br />
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===Cdc25===
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[[1qb0]], [[1cwr]], [[1cws]], [[1cwt]], [[1ym9]], [[1ymd]], [[1ymk]], [[1yml]], [[1ys0]], [[2uzq]] – hCdc25B catalytic domain <br />
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[[2a2k]], [[2ifd]], [[2ifv]] – hCdc25B catalytic domain (mutant)<br />
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===Phosphoinositide phosphatase PTEN===
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[[1d5r]] – hPTEN (mutant)<br />
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===Myotubularin-related protein (MTMR)===
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[[1zvr]] – hMTMR2 PH-gram and phosphatase domains (mutant)<br />
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[[1zsq]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphatidylinositol 3-phosphate<br />
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[[1m7r]], [[1lw3]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate<br />
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[[2yf0]] – hMTMR6<br />
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===MAPK phosphatase===
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[[MAP kinase phosphatase]]
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[[Category:Topic Page]]

Revision as of 08:54, 19 June 2014

Template:STRUCTURE 1ohe

Dual specificity phosphatase (DUSP) is a phosphatase which acts on tyrosine, serine or threonine residues. There are several DUSP enzymes in mammals sharing a common catalytic mechanism. The DUSP include:
• Slingshot phosphatase
• Phosphatase of regenerating liver
• Cdc14
• Cdc25
• PTEN
• Myotubularin
• MAPK phosphatase see MAP kinase phosphatase

3D structures of dual specificity phosphatase

Updated on 19-June-2014

slingshot phosphatase (SSH)

2nt2 – hSSH-2L catalytic domain - human

Phosphatase of regenerating liver (RPL)

1xm2 – hPRL-1 (mutant)
1zck, 1x24 – rPRL-1 - rat
1zcl – rPRL-1 (mutant)
1r6h, 1v3a, 2mbc – hPRL-3 - NMR

Cdc14

1ohc, 1ohd – hCdc14B2 core domain
1ohe – hCdc14B2 core domain + peptide

Cdc25

1qb0, 1cwr, 1cws, 1cwt, 1ym9, 1ymd, 1ymk, 1yml, 1ys0, 2uzq – hCdc25B catalytic domain
2a2k, 2ifd, 2ifv – hCdc25B catalytic domain (mutant)

Phosphoinositide phosphatase PTEN

1d5r – hPTEN (mutant)

Myotubularin-related protein (MTMR)

1zvr – hMTMR2 PH-gram and phosphatase domains (mutant)
1zsq - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphatidylinositol 3-phosphate
1m7r, 1lw3 - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate
2yf0 – hMTMR6

MAPK phosphatase

MAP kinase phosphatase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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