Monooxygenase

Function

Monooxygenases (MO) catalyzes the incorporation of a hydroxyl group into a variety of substrates. MO catalyzes the reduction of O2 to H2O while oxidating NADPH.

Disease

Relevance

Structural highlights

3D structures of monooxygenase

Updated on 23-June-2014

Toluene 4-monooxygenase (TMO)

3dhg, 3i5j – PmTMO α+β+γ subunits + Fe – Pseudomonas mendocina

TMO complexes

3dhh, 3q3n, 3q3o – PmTMO α+β+γ subunits + Fe + phenol derivative + TMO system effector protein
3rmk – PmTMO α+β+γ subunits + Fe + phenol derivative
3q14 – PmTMO α+β+γ subunits + Fe + p-cresol + TMO system effector protein
3q2a, 3q3m – PmTMO α+β+γ subunits + Fe + benzoate inhibitor + TMO system effector protein
3dhi – PmTMO α+β+γ subunits + Fe + TMO system effector protein
3ge3, 3ge8, 3ri7 – PmTMO α (mutant)+β+γ subunits + Fe + TMO system effector protein
3i63 – PmTMO α+β+γ subunits + Fe + TMO system effector protein + H2O2

Luceferin 4-monooxygenase and Alkanal monooxygenase

See Luciferase

Heme-degrading monooxygenase (IsdI)

2zdp – SaIsdI + heme-Co – Staphylococcus aureus
3lgm – SaIsdI + heme-Fe
4fnh – SaIsdI (mutant) + heme-Fe
3lgn – SaIsdI + heme-Fe + O2
3qgp – SaIsdI + heme-Fe + CN
4fni – SaIsdI (mutant) + heme-Fe + CN

Kynurenine 3-monooxygenase (KMO)

4j2w, 4j31, 4j33, 4j34 – yKMO + FAD – yeast
4j36 – yKMO + FAD + inhibitor

===Phenol 2-monooxygenase (PMO===)

1foh – TcPMO + FAD – Trichosporon cutaneum

1pn0 – TcPMO + FAD + phenol

References