4b1b

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[[Image:4b1b.png|left|200px]]
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==Crystal structure of Plasmodium falciparum oxidised Thioredoxin Reductase at 2.9 angstrom==
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<StructureSection load='4b1b' size='340' side='right' caption='[[4b1b]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4b1b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B1B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B1B FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene><br>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b1b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b1b RCSB], [http://www.ebi.ac.uk/pdbsum/4b1b PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Plasmodium falciparum is the vector of the most prevalent and deadly form of malaria, and, among the Plasmodium species, it is the one with the highest rate of drug resistance. At the basis of a rational drug design project there is the selection and characterization of suitable target(s). Thioredoxin reductase, the first protection against reactive oxygen species in the erythrocytic phase of the parasite, is essential for its survival. Hence it represents a good target for the design of new anti-malarial active compounds. In this paper we present the first crystal structure of recombinant P. falciparum thioredoxin reductase (PfTrxR) at 2.9A and discuss its differences with respect to the human orthologue. The most important one resides in the dimer interface, which offers a good binding site for selective non competitive inhibitors. The striking conservation of this feature among the Plasmodium parasites, but not among other Apicomplexa parasites neither in mammals, boosts its exploitability.
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{{STRUCTURE_4b1b| PDB=4b1b | SCENE= }}
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Crystal structure of Plasmodium falciparum thioredoxin reductase, a validated drug target.,Boumis G, Giardina G, Angelucci F, Bellelli A, Brunori M, Dimastrogiovanni D, Saccoccia F, Miele AE Biochem Biophys Res Commun. 2012 Aug 6. PMID:22889878<ref>PMID:22889878</ref>
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===Crystal structure of Plasmodium falciparum oxidised Thioredoxin Reductase at 2.9 angstrom===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_22889878}}
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==See Also==
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*[[Thioredoxin Reductase|Thioredoxin Reductase]]
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==About this Structure==
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== References ==
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[[4b1b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B1B OCA].
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:022889878</ref><references group="xtra"/>
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[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
[[Category: Thioredoxin-disulfide reductase]]
[[Category: Thioredoxin-disulfide reductase]]

Revision as of 06:48, 25 June 2014

Crystal structure of Plasmodium falciparum oxidised Thioredoxin Reductase at 2.9 angstrom

4b1b, resolution 2.90Å

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