Histidine triad nucleotide-binding protein

Function

Histidine triad nucleotide-binding protein (HINT) or protein kinase C interacting protein hydrolyzes purine nucleotide monophosphoamidates and some amino acid-AMPs. HINT is also a tumor suppressor. Fragile histidine triad (FHIT) cleave diadenosine polyphosphates like ApppA. FHIT-Ap(n)A complex functions in proapoptotic tumor suppression pathway.

Disease

Relevance

Structural highlights

3D structures of histidine triad nucleotide-binding protein

Updated on 30-June-2014

HINT1

1kpa, 1kpb, 1kpc – hHINT – human
6rhn – rHINT - rabbit
3o1z – rHINT (mutant)

HINT1 complexes

3rhn – rHINT + GMP

4rhn, 3qgz – rHINT + adenosine
5rhn – rHINT + 8-Br-AMP
1av5, 1kpe – hHINT + adenosine derivative
1kpf, 3tw2 – hHINT + AMP
1rzy – rHINT + adenosine derivative
3o1c, 3o1x – rHINT (mutant) + adenosine
4eqe – hHINT + Lys-AMS
4eqg – hHINT + Ala-AMS
4eqh – hHINT + Trp-AMS

HINT2

4inc, 4njx, 4njy, 4njz, 4nk0 – hHINT
4ini – hHINT + AMP

FHIT

1fit, 2fit, 4fit – hFHIT
3fit – hFHIT + AMP
5fit, 6fit – hFHIT + adenosine derivative
1fhi – hFHIT + ApppA derivative
2fhi – hFHIT (mutant) + ApppA derivative

References