Histidine triad nucleotide-binding protein
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='3rhn' size='340' side='right' caption='Structure of rabbit HINT1 complex with GMP (PDB code 3rhn).' scene=''> == Function == '''Histidine triad nucleotide-bi...) |
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<StructureSection load='3rhn' size='340' side='right' caption='Structure of rabbit HINT1 complex with GMP (PDB code [[3rhn]]).' scene=''> | <StructureSection load='3rhn' size='340' side='right' caption='Structure of rabbit HINT1 complex with GMP (PDB code [[3rhn]]).' scene=''> | ||
== Function == | == Function == | ||
| - | '''Histidine triad nucleotide-binding protein''' (HINT) or ''protein kinase C interacting protein'' hydrolyzes purine nucleotide monophosphoamidates and some amino acid-AMPs. HINT is also a tumor suppressor. '''Fragile histidine triad''' (FHIT) cleave diadenosine polyphosphates like ApppA. FHIT-Ap(n)A complex functions in proapoptotic tumor suppression pathway. | + | '''Histidine triad nucleotide-binding protein''' (HINT) or '''protein kinase C interacting protein''' hydrolyzes purine nucleotide monophosphoamidates and some amino acid-AMPs. HINT is also a tumor suppressor. '''Fragile histidine triad''' (FHIT) cleave diadenosine polyphosphates like ApppA. FHIT-Ap(n)A complex functions in proapoptotic tumor suppression pathway. |
== Disease == | == Disease == | ||
Revision as of 08:48, 30 June 2014
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