Function
Arginase (Arg) catalyzes the conversion of arginine to ornithine and urea. Arg is the final enzyme in the urea cycle. Arg requires 2 manganese ions for functioning.
Disease
Relevance
Structural highlights
3D structures of arginase
Updated on 03-July-2014
3tf3 – hArg - human
Mn containing arginase
1rla, 2rla – rArg + Mn – rat
3rla, 4rla, 5rla, 1hqx, 1p8m, 1p8n, 1p8o, 1p8p, 1p8q, 1p8r, 1p8s, 1ta1, 1tbh, 1tbj, 1tbl, 3e8q, 3e8z – rArg (mutant) + Mn
1wva, 2pha, 2zav – hArg + Mn
1wvb – hArg (mutant) + Mn
Mn containing arginase complexes
1d3v, 1hq5 – rArg + Mn + Arg analog
1hqf, 1hqh – rArg + Mn + hydroxyl-Arg
1hqg – rArg (mutant) + Mn + ornithine + urea
1r1o, 1t4p, 1t4r, 1t4t, 1t5f – rArg + Mn + inhibior
1t4s – rArg + Mn + valine
1t5g – rArg + Mn + Arg
1zpe, 1zpg – rArg Mutant) + Mn + alkylamine derivative
3e9b – rArg (mutant) + Mn + Br-ethyl cysteine
2aeb, 2pll – hArg + Mn + Arg analog
2pho – hArg + Mn + thiosemicarbazide
3dj8 – hArg + Mn + amino-epoxy octanoic acid
3e6k, 3e6v – hArg (mutant) + Mn + Arg analog
3f80 – hArg + Mn + nitro-norleucine
3kv2, 3lp7 – hArg + Mn + nor-ω-hydroxy-Arg
3gmz – hArg + Mn + ornithine
3gn0 – hArg + Mn + ornithine derivative
3lp4 – hArg + Mn + lysine
3mfv, 3mfw – hArg + Mn + histidine derivative
3mjl – hArg + Mn + amino-imidazole
3sjt, 3skk, 4hww, 4hxq, 4ie1 – hArg + Mn + inhibitor
4fci – hArg + Mn + amino-guanidino propionate
Co containing arginase
3th7, 3the – hArg + Co
3thh – hArg + Co + Arg analog
3thj – hArg + Co + ornithine
4fck – hArg + Co + amino-guanidino propionate
Ni containing arginase
4gsm – hArg + Ni
4gsv – hArg + Ni + Arg analog
Zn containing arginase
4gsz – hArg + Zn + Arg analog
Mn and Zn containing arginase
4gwc – hArg + Mn + Zn
4gwd – hArg + Mn + Zn + Arg analog
References
