Function
Azurin (AZ) is a blue copper protein. AZ mediates electron transfer and contains type I copper center.
Disease
Relevance
AZ was found to be a novel anticancer agent. Following the entry of the P. aeruginosa bacteria into human melanoma and breast cancer cells, the AZ complexes with the tumor suppressor p53. The complex stabilizes p53 and activates the apoptosis of the cancer cells.
Structural highlights
3D structures of cAMP-dependent protein kinase
Updated on 08-July-2014
1e65 – PaAZ – Pseudomonas aeruginosa
Cu+2 containing azurin
1azu, 1azr, 4azu, 5azu, 1azn, 1cc3, 1e5y, 1e5z, 1jze, 2ft6, 2ft7, 2ft8, 2fta, 3fs9, 3fsa, 3fsv, 3fsw, 3fsz, 3ft0 – PaAZ
1joi – PfAZ – Pseudomonas fluorrescens
1nwo – PpAZ – Pseudomonas putida
1nwp – PpAZ + Zn+2
2aza, 1azb, 1azc – AxAZ – Achromobacter xylosoxidans
2azu, 3azu, 1ils, 1ilu, 2tsa, 2tsb, 1etj, 1ag0, 1ezl, 1jvo, 1gr7, 1xb3, 1xb6, 1xb8, 2ghz, 2hx7, 2oj1, 3in0, 3fpy, 3fq1, [3fq2]], 3fqy, 3in2, 3jt2, 3jtb, 3np3, 3np4, 3oqr, 3n2j, 3u25, 4hhw, 4mfh, 4ko5, 4ko6, 4ko7, 4ko9, 4kob, 4koc, 4bww – PaAZ (mutant)
1jvl, 2idf – PaAZ (mutant) + Ni+2
1uri, 1a4a, 1a4b, 1a4c – AdAZ (mutant)
2h3x, 2h47, 2iaa – AZ + aromatic amine dehydrogenase – Alcaligenes faecalis
Cu+2 containing lanthanide-modified azurin
1bex, 1jzi, 1jze, 1jzf, 1jzj, 1jsh – PaAZ
2i7s, 2fnw, 2i7o, 3ibo, 4hhg, 4k9j – PaAZ (mutant)
Cu+1 containing azurin
1jzg – PaAZ
1r1c, 2gi0, 1i53, 2hx8, 2hx9, 2hxa, 2xv0, 2xv2, 2xv3 – PaAZ (mutant)
Non-Cu+2 containing azurin
1aiz – AdAZ + Cd+2 – Achromobacter denitrificans
1nzr – PaAZ (mutant) + Ni+2
1vlx – PaAZ + Co+2
1e67 – PaAZ + Zn+2
2iwe – PaAZ (mutant) + Zn+2
3uge – PaAZ + Ag+1
4hz1 – PaAZ + Fe+2
4jkn – PaAZ + Hg+2
References
