1cic

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[[Image:1cic.jpg|left|200px]]<br /><applet load="1cic" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1cic.jpg|left|200px]]
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caption="1cic, resolution 2.5&Aring;" />
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'''IDIOTOPE-ANTI-IDIOTOPE FAB-FAB COMPLEX; D1.3-E225'''<br />
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{{Structure
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|PDB= 1cic |SIZE=350|CAPTION= <scene name='initialview01'>1cic</scene>, resolution 2.5&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''IDIOTOPE-ANTI-IDIOTOPE FAB-FAB COMPLEX; D1.3-E225'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1CIC is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CIC OCA].
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1CIC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CIC OCA].
==Reference==
==Reference==
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Three-dimensional structure of an idiotope-anti-idiotope complex., Bentley GA, Boulot G, Riottot MM, Poljak RJ, Nature. 1990 Nov 15;348(6298):254-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1700305 1700305]
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Three-dimensional structure of an idiotope-anti-idiotope complex., Bentley GA, Boulot G, Riottot MM, Poljak RJ, Nature. 1990 Nov 15;348(6298):254-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1700305 1700305]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: immunoglobulin]]
[[Category: immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:06:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:24:44 2008''

Revision as of 08:24, 20 March 2008

Image:1cic.jpg


PDB ID 1cic

Drag the structure with the mouse to rotate
, resolution 2.5Å
Coordinates: save as pdb, mmCIF, xml



IDIOTOPE-ANTI-IDIOTOPE FAB-FAB COMPLEX; D1.3-E225


Overview

Serologically detected antigenic determinants unique to an antibody or group of antibodies are called idiotopes. The sum of idiotopes of an antibody constitute its idiotype. Idiotypes have been intensively studied following a hypothesis for the self-regulation of the immune system through a network of idiotype-anti-idiotype interactions. Furthermore, as antigen and anti-idiotypes can competitively bind to idiotype-positive, antigen-specific antibodies, anti-idiotypes may carry an 'internal image' of the external antigen. Here we describe the structure of the complex between the monoclonal anti-lysozyme FabD1.3 and the anti-idiotopic FabE225 at 2.5 A resolution. This complex defines a private idiotope consisting of 13 amino-acid residues, mainly from the complementarity-determining regions of D1.3. Seven of these residues make contacts with the antigen, indicating a significant overlap between idiotope and antigen-combining site. Idiotopic mimicry of the external antigen is not achieved at the molecular level in this example.

About this Structure

1CIC is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of an idiotope-anti-idiotope complex., Bentley GA, Boulot G, Riottot MM, Poljak RJ, Nature. 1990 Nov 15;348(6298):254-7. PMID:1700305

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