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1cit
From Proteopedia
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| - | [[Image:1cit.gif|left|200px]] | + | [[Image:1cit.gif|left|200px]] |
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| - | '''DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B''' | + | {{Structure |
| + | |PDB= 1cit |SIZE=350|CAPTION= <scene name='initialview01'>1cit</scene>, resolution 2.7Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1CIT is a [ | + | 1CIT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CIT OCA]. |
==Reference== | ==Reference== | ||
| - | DNA-binding mechanism of the monomeric orphan nuclear receptor NGFI-B., Meinke G, Sigler PB, Nat Struct Biol. 1999 May;6(5):471-7. PMID:[http:// | + | DNA-binding mechanism of the monomeric orphan nuclear receptor NGFI-B., Meinke G, Sigler PB, Nat Struct Biol. 1999 May;6(5):471-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10331876 10331876] |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: early immediate response gene product]] | [[Category: early immediate response gene product]] | ||
| - | [[Category: minor groove | + | [[Category: minor groove interaction]] |
[[Category: monomeric protein-dna complex]] | [[Category: monomeric protein-dna complex]] | ||
[[Category: orphan nuclear receptor]] | [[Category: orphan nuclear receptor]] | ||
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[[Category: transcription factor]] | [[Category: transcription factor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:24:58 2008'' |
Revision as of 08:25, 20 March 2008
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| , resolution 2.7Å | |||||||
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| Ligands: | |||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B
Overview
The 2.7 A X-ray crystal structure of the DNA-binding domain (DBD) of the orphan nuclear receptor, nerve growth factor-induced-B (NGFI-B), complexed to its high-affinity DNA target, represents the first structure analysis of a nuclear receptor DBD bound as a monomer to DNA. The structure of the core DBD and its interactions with the major groove of the DNA are similar to previously crystallographically solved DBD-DNA complexes in this superfamily; however, residues C-terminal to this core form a separate and unique substructure that interacts extensively and in a sequence-specific way with the minor groove of its DNA target, in particular with the characteristic 3 A-T base-pair identity element that extends 5' to the usual nuclear receptor half-site (AGGTCA).
About this Structure
1CIT is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
DNA-binding mechanism of the monomeric orphan nuclear receptor NGFI-B., Meinke G, Sigler PB, Nat Struct Biol. 1999 May;6(5):471-7. PMID:10331876
Page seeded by OCA on Thu Mar 20 10:24:58 2008
