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1cmi
From Proteopedia
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| - | [[Image:1cmi.gif|left|200px]] | + | [[Image:1cmi.gif|left|200px]] |
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| - | '''STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE''' | + | {{Structure |
| + | |PDB= 1cmi |SIZE=350|CAPTION= <scene name='initialview01'>1cmi</scene>, resolution 2.5Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1CMI is a [ | + | 1CMI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1B1W. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CMI OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of the PIN/LC8 dimer with a bound peptide., Liang J, Jaffrey SR, Guo W, Snyder SH, Clardy J, Nat Struct Biol. 1999 Aug;6(8):735-40. PMID:[http:// | + | Structure of the PIN/LC8 dimer with a bound peptide., Liang J, Jaffrey SR, Guo W, Snyder SH, Clardy J, Nat Struct Biol. 1999 Aug;6(8):735-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10426949 10426949] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: dynein light chain]] | [[Category: dynein light chain]] | ||
[[Category: lc8]] | [[Category: lc8]] | ||
| - | [[Category: | + | [[Category: nno]] |
[[Category: pin]] | [[Category: pin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:26:12 2008'' |
Revision as of 08:26, 20 March 2008
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| , resolution 2.5Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE
Contents |
Overview
The structure of the protein known both as neuronal nitric oxide synthase inhibitory protein, PIN (protein inhibitor of nNOS), and also as the 8 kDa dynein light chain (LC8) has been solved by X-ray diffraction. Two PIN/LC8 monomers related by a two-fold axis form a rectangular dimer. Two pairs of alpha-helices cover opposite faces, and each pair of helices packs against a beta-sheet with five antiparallel beta-strands. Each five-stranded beta-sheet contains four strands from one monomer and a fifth strand from the other monomer. A 13-residue peptide from nNOS is bound to the dimer in a deep hydrophobic groove as a sixth antiparallel beta-strand. The structure provides key insights into dimerization of and peptide binding by the multifunctional PIN/LC8 protein.
Disease
Known diseases associated with this structure: Colorectal cancer, somatic OMIM:[604258], Esophageal cancer OMIM:[604050], Lung cancer OMIM:[604050]
About this Structure
1CMI is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1B1W. Full crystallographic information is available from OCA.
Reference
Structure of the PIN/LC8 dimer with a bound peptide., Liang J, Jaffrey SR, Guo W, Snyder SH, Clardy J, Nat Struct Biol. 1999 Aug;6(8):735-40. PMID:10426949
Page seeded by OCA on Thu Mar 20 10:26:12 2008
Categories: Homo sapiens | Single protein | Clardy, J. | Guo, W. | Jaffery, S. | Liang, J. | Snyder, S. | Dynein light chain | Lc8 | Nno | Pin
