Ephrin

Function

Ephrins (Eph) are the membrane-bound ligands of ephrin receptors. The binding of Eph and ephrin receptors is achieved via cell-cell interaction. Eph/Eph receptor signaling regulates embryonic development, guidance of axon growth, long-term potentiation, angiogenesis and stem-cell differentiation.

Disease

Relevance

Structural highlights

3D structures of ephrin

Updated on 16-July-2014

Ephrin-A5

1shx – mEph receptor-binding domain – mouse
1shw – mEph residues 88-225 + Eph type B receptor 2
2x11, 3mx0 – hEph receptor-binding domain + Eph type A receptor 2 - human
4bk5, 4bka, 4m4r – hEph receptor-binding domain + Eph type A receptor 4
4l0p – hEph receptor-binding domain + Eph type A receptor 3

Ephrin-B2

2i85 – hEph residues 1-142 – NMR
1iko – mEph ectodomain
1kgy – mEph receptor-binding domain + Eph type B receptor 2
2hle – mEph receptor-binding domain + Eph type B receptor 4
2wo2, 3gxu – hEph receptor-binding domain + Eph type A receptor 4
2vsk, 2vsm – hEph receptor-binding domain + virus hemagglutinin neuraminidase

Ephrin-B3

3d12 – mEph receptor-binding domain + virus hemagglutinin neuraminidase
4bkf – hEph receptor-binding domain + Eph type A receptor 4

Ephrin-A1

3hei, 3mbw – hEph receptor-binding domain + Eph type A receptor 2

Ephrin-A2

2wo3 – hEph receptor-binding domain + Eph type A receptor 4

References