2lk7

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[[Image:2lk7.jpg|left|200px]]
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==Monomer-dimer equilibrium for 5'-5' stacking of propeller-type parallel-stranded G-quadruplexes: NMR structural study==
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<StructureSection load='2lk7' size='340' side='right' caption='[[2lk7]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2lk7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LK7 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lk7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lk7 RCSB], [http://www.ebi.ac.uk/pdbsum/2lk7 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Guanine-rich sequence motifs, which contain tracts of three consecutive guanines connected by single non-guanine nucleotides, are abundant in the human genome and can form a robust G-quadruplex structure with high stability. Herein, by using NMR spectroscopy, we investigate the equilibrium between monomeric and 5'-5' stacked dimeric propeller-type G-quadruplexes that are formed by DNA sequences containing GGGT motifs. We show that the monomer-dimer equilibrium depends on a number of parameters, including the DNA concentration, DNA flanking sequences, the concentration and type of cations, and the temperature. We report on the high-definition structure of a simple monomeric G-quadruplex containing three single-residue loops, which could serve as a reference for propeller-type G-quadruplex structures in solution.
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{{STRUCTURE_2lk7| PDB=2lk7 | SCENE= }}
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Monomer-Dimer Equilibrium for the 5'-5' Stacking of Propeller-Type Parallel-Stranded G-Quadruplexes: NMR Structural Study.,Do NQ, Phan AT Chemistry. 2012 Sep 27. doi: 10.1002/chem.201103295. PMID:23019076<ref>PMID:23019076</ref>
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===Monomer-dimer equilibrium for 5'-5' stacking of propeller-type parallel-stranded G-quadruplexes: NMR structural study===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_23019076}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2lk7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LK7 OCA].
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</StructureSection>
[[Category: Do, N Q.]]
[[Category: Do, N Q.]]
[[Category: Phan, A T.]]
[[Category: Phan, A T.]]

Revision as of 10:45, 16 July 2014

Monomer-dimer equilibrium for 5'-5' stacking of propeller-type parallel-stranded G-quadruplexes: NMR structural study

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