1csm
From Proteopedia
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| - | [[Image:1csm.gif|left|200px]] | + | [[Image:1csm.gif|left|200px]] |
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| - | '''THE CRYSTAL STRUCTURE OF ALLOSTERIC CHORISMATE MUTASE AT 2.2 ANGSTROMS RESOLUTION''' | + | {{Structure |
| + | |PDB= 1csm |SIZE=350|CAPTION= <scene name='initialview01'>1csm</scene>, resolution 2.2Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Anthranilate_synthase Anthranilate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.27 4.1.3.27] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''THE CRYSTAL STRUCTURE OF ALLOSTERIC CHORISMATE MUTASE AT 2.2 ANGSTROMS RESOLUTION''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1CSM is a [ | + | 1CSM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CSM OCA]. |
==Reference== | ==Reference== | ||
| - | The crystal structure of allosteric chorismate mutase at 2.2-A resolution., Xue Y, Lipscomb WN, Graf R, Schnappauf G, Braus G, Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10814-8. PMID:[http:// | + | The crystal structure of allosteric chorismate mutase at 2.2-A resolution., Xue Y, Lipscomb WN, Graf R, Schnappauf G, Braus G, Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10814-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7971967 7971967] |
[[Category: Anthranilate synthase]] | [[Category: Anthranilate synthase]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
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[[Category: isomerase]] | [[Category: isomerase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:28:26 2008'' |
Revision as of 08:28, 20 March 2008
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| , resolution 2.2Å | |||||||
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| Ligands: | |||||||
| Activity: | Anthranilate synthase, with EC number 4.1.3.27 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE CRYSTAL STRUCTURE OF ALLOSTERIC CHORISMATE MUTASE AT 2.2 ANGSTROMS RESOLUTION
Overview
The crystal structure of an allosteric chorismate mutase, the Thr-226-->Ile mutant, from yeast Saccharomyces cerevisiae has been determined to 2.2-A resolution by using the multiple isomorphous replacement method. Solvent-flattening and electron-density modification were applied for phase improvement. The current crystallographic R factor is 0.196. The final model includes 504 of the 512 residues and 97 water molecules. In addition, two tryptophan molecules were identified in the interface between monomers. The overall structure is completely different from the reported structure of chorismate mutase from Bacillus subtilis. This structure showed 71% helices with essentially no beta-sheet structures.
About this Structure
1CSM is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
The crystal structure of allosteric chorismate mutase at 2.2-A resolution., Xue Y, Lipscomb WN, Graf R, Schnappauf G, Braus G, Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10814-8. PMID:7971967
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