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4tko
From Proteopedia
(Difference between revisions)
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tko OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tko RCSB], [http://www.ebi.ac.uk/pdbsum/4tko PDBsum]</span></td></tr> | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tko FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tko OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tko RCSB], [http://www.ebi.ac.uk/pdbsum/4tko PDBsum]</span></td></tr> | ||
<table> | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Periplasmic adaptor proteins are key components of bacterial tripartite efflux pumps. The 2.85A resolution structure of an MFS (major facilitator superfamily) pump adaptor, Aquifex aeolicus EmrA, shows linearly arranged alpha-helical coiled-coil, lipoyl, and beta-barrel domains, but lacks the fourth membrane-proximal domain shown in other pumps to interact with the inner membrane transporter. The adaptor alpha-hairpin, which binds outer membrane TolC, is exceptionally long at 127A, and the beta-barrel contains a conserved disordered loop. The structure extends the view of adaptors as flexible, modular components that mediate diverse pump assembly, and suggests that in MFS tripartite pumps a hexamer of adaptors could provide a periplasmic seal. | ||
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| + | Structure of the periplasmic adaptor protein from a major facilitator superfamily (MFS) multidrug efflux pump.,Hinchliffe P, Greene NP, Paterson NG, Crow A, Hughes C, Koronakis V FEBS Lett. 2014 Jul 1. pii: S0014-5793(14)00519-5. doi:, 10.1016/j.febslet.2014.06.055. PMID:24996185<ref>PMID:24996185</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 06:36, 23 July 2014
Structure of the periplasmic adaptor protein EmrA
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