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2ch9
From Proteopedia
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[[Category: thiol protease inhibitor]] | [[Category: thiol protease inhibitor]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 17:08:19 2007'' |
Revision as of 15:03, 30 October 2007
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CRYSTAL STRUCTURE OF DIMERIC HUMAN CYSTATIN F
Overview
Cystatins are important natural cysteine protease inhibitors targeting, primarily papain-like cysteine proteases, including cathepsins and, parasitic proteases like cruzipain, but also mammalian asparaginyl, endopeptidase. Mammalian cystatin F, which is expressed almost exclusively, in hematopoietic cells and accumulates in lysosome-like organelles, has, been implicated in the regulation of antigen presentation and other immune, processes. It is an unusual cystatin superfamily member with a, redox-regulated activation mechanism and a restricted specificity profile., We describe the 2.1A crystal structure of human cystatin F in its dimeric, "off" state. The two monomers interact in a fashion not seen before for, cystatins or cystatin-like proteins that is crucially dependent on an, unusual ... [(full description)]
About this Structure
2CH9 is a [Single protein] structure of sequence from [Homo sapiens] with NAG, ZN and ACT as [ligands]. Structure known Active Site: AC6. Full crystallographic information is available from [OCA].
Reference
Structural basis of reduction-dependent activation of human cystatin F., Schuttelkopf AW, Hamilton G, Watts C, van Aalten DM, J Biol Chem. 2006 Jun 16;281(24):16570-5. Epub 2006 Apr 6. PMID:16601115
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