1cx8
From Proteopedia
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| - | [[Image:1cx8.gif|left|200px]] | + | [[Image:1cx8.gif|left|200px]] |
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| - | '''CRYTAL STRUCTURE OF THE ECTODOMAIN OF HUMAN TRANSFERRIN RECEPTOR''' | + | {{Structure |
| + | |PDB= 1cx8 |SIZE=350|CAPTION= <scene name='initialview01'>1cx8</scene>, resolution 3.2Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=SM:SAMARIUM (III) ION'>SM</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''CRYTAL STRUCTURE OF THE ECTODOMAIN OF HUMAN TRANSFERRIN RECEPTOR''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1CX8 is a [ | + | 1CX8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1CX8 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb35_1.html Ferritin and Transferrin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CX8 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the ectodomain of human transferrin receptor., Lawrence CM, Ray S, Babyonyshev M, Galluser R, Borhani DW, Harrison SC, Science. 1999 Oct 22;286(5440):779-82. PMID:[http:// | + | Crystal structure of the ectodomain of human transferrin receptor., Lawrence CM, Ray S, Babyonyshev M, Galluser R, Borhani DW, Harrison SC, Science. 1999 Oct 22;286(5440):779-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10531064 10531064] |
[[Category: Ferritin and Transferrin]] | [[Category: Ferritin and Transferrin]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: human transferrin receptor]] | [[Category: human transferrin receptor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:30:04 2008'' |
Revision as of 08:30, 20 March 2008
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| , resolution 3.2Å | |||||||
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYTAL STRUCTURE OF THE ECTODOMAIN OF HUMAN TRANSFERRIN RECEPTOR
Overview
The transferrin receptor (TfR) undergoes multiple rounds of clathrin-mediated endocytosis and reemergence at the cell surface, importing iron-loaded transferrin (Tf) and recycling apotransferrin after discharge of iron in the endosome. The crystal structure of the dimeric ectodomain of the human TfR, determined here to 3.2 angstroms resolution, reveals a three-domain subunit. One domain closely resembles carboxy- and aminopeptidases, and features of membrane glutamate carboxypeptidase can be deduced from the TfR structure. A model is proposed for Tf binding to the receptor.
About this Structure
1CX8 is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1CX8 with [Ferritin and Transferrin]. Full crystallographic information is available from OCA.
Reference
Crystal structure of the ectodomain of human transferrin receptor., Lawrence CM, Ray S, Babyonyshev M, Galluser R, Borhani DW, Harrison SC, Science. 1999 Oct 22;286(5440):779-82. PMID:10531064
Page seeded by OCA on Thu Mar 20 10:30:04 2008
