4q7d
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Wild type Fc (wtFc)== |
| + | <StructureSection load='4q7d' size='340' side='right' caption='[[4q7d]], [[Resolution|resolution]] 2.35Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4q7d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q7D FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene><br> | ||
| + | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q74|4q74]], [[4q6y|4q6y]]</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q7d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q7d RCSB], [http://www.ebi.ac.uk/pdbsum/4q7d PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4. | ||
| + | == Function == | ||
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Ahmed, A A.]] | |
| - | + | [[Category: Bjorkman, P J.]] | |
| - | + | [[Category: Giddens, J.]] | |
| + | [[Category: Lomino, J V.]] | ||
| + | [[Category: Pincetic, A.]] | ||
| + | [[Category: Ravetch, J V.]] | ||
| + | [[Category: Wang, L X.]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Immunoglobulin fold]] | ||
Revision as of 08:11, 23 July 2014
Wild type Fc (wtFc)
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