4qtb
From Proteopedia
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| - | ''' | + | ==Structure of human ERK1 in complex with SCH772984 revealing a novel inhibitor-induced binding pocket== |
| - | + | <StructureSection load='4qtb' size='340' side='right' caption='[[4qtb]], [[Resolution|resolution]] 1.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4qtb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QTB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QTB FirstGlance]. <br> | |
| - | + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=38Z:(3R)-1-(2-OXO-2-{4-[4-(PYRIMIDIN-2-YL)PHENYL]PIPERAZIN-1-YL}ETHYL)-N-[3-(PYRIDIN-4-YL)-2H-INDAZOL-5-YL]PYRROLIDINE-3-CARBOXAMIDE'>38Z</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br> | |
| - | + | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qta|4qta]], [[4qtc|4qtc]], [[4qtd|4qtd]], [[4qte|4qte]]</td></tr> | |
| - | + | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr> | |
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qtb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qtb RCSB], [http://www.ebi.ac.uk/pdbsum/4qtb PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Mitogen-activated protein kinase]] | ||
| + | [[Category: Arrowsmith, C H.]] | ||
| + | [[Category: Bountra, C.]] | ||
| + | [[Category: Chaikuad, A.]] | ||
| + | [[Category: Delft, F von.]] | ||
| + | [[Category: Edwards, A M.]] | ||
| + | [[Category: Keates, T.]] | ||
| + | [[Category: Knapp, S.]] | ||
| + | [[Category: SGC, Structural Genomics Consortium.]] | ||
| + | [[Category: Allosteric]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Kinase]] | ||
| + | [[Category: Mapk]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Signalling]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Structural genomics consortium]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 08:14, 23 July 2014
Structure of human ERK1 in complex with SCH772984 revealing a novel inhibitor-induced binding pocket
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Categories: Mitogen-activated protein kinase | Arrowsmith, C H. | Bountra, C. | Chaikuad, A. | Delft, F von. | Edwards, A M. | Keates, T. | Knapp, S. | SGC, Structural Genomics Consortium. | Allosteric | Inhibitor | Kinase | Mapk | Sgc | Signalling | Structural genomic | Structural genomics consortium | Transferase | Transferase-transferase inhibitor complex
