This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Krebs cycle step 7
From Proteopedia
Verena Pietzner (Talk | contribs)
(New page: <h2>Step 7 of the Krebs cycle: Fumarase</h2> Image:fumarase_2.jpg <p>Figure: Formation of L-Malate</p> <p>L-malate is formed out of fumarate by adding water to the double bond; there...)
Next diff →
Revision as of 07:43, 28 July 2014
Step 7 of the Krebs cycle: Fumarase
Figure: Formation of L-Malate
L-malate is formed out of fumarate by adding water to the double bond; therefore, the reaction type is a hydration. The reaction process is unusual becaue the first step is the addition of OH-. As a result, a negativley charged carbanion is formed. The addition of the proton on the opposite side of the hydroxy group, leads to the formation of L-malate. The catalysing enzyme fumarase is highly stereospecific, which can be seen from the fact that only L-malate is formed as a product and not a mixture of D-malate and L-malate.
