Kallikrein

Function

Kallikrein (KLK) is a serine protease. Plasma KLK releases the peptides bradykinin and kallidin from kininogen and plasmin from plasminogen. Tissue KLK participates in the regulation of blood pressure by activation of bradykinin.

Disease

Relevance

Structural highlights

3D Structures of kallikrein

Updated on 29-July-2014

Kallikrein 4

4kga – hKLK + Ni - human
2bdg – hKLK + aminobenzamidine + Ni
2bdh – hKLK + aminobenzamidine + Zn
2bdi – hKLK + aminobenzamidine + Co
4k1e, 4kel, 4k8y – hKLK + trypsin inhibitor

Kallikrein 5

2psx – hKLK catalytic domain + leupeptin
2psy – hKLK catalytic domain + leupeptin + Zn

Kallikrein 13

1ao5 – KLK - mouse

Plasma kallikrein

2anw, 2any – hKLK catalytic domain (mutant) + benzamidine
4ogx, 4ogy – hKLK catalytic domain (mutant) + antibody

Tissue kallikrein (KLK 1)

1spj – hKLK (mutant)

References