1d32

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[[Image:1d32.jpg|left|200px]]<br /><applet load="1d32" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1d32.jpg|left|200px]]
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caption="1d32, resolution 1.700&Aring;" />
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'''DRUG-INDUCED DNA REPAIR: X-RAY STRUCTURE OF A DNA-DITERCALINIUM COMPLEX'''<br />
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{{Structure
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|PDB= 1d32 |SIZE=350|CAPTION= <scene name='initialview01'>1d32</scene>, resolution 1.700&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=DIT:DITERCALINIUM'>DIT</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''DRUG-INDUCED DNA REPAIR: X-RAY STRUCTURE OF A DNA-DITERCALINIUM COMPLEX'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1D32 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=DIT:'>DIT</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D32 OCA].
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1D32 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D32 OCA].
==Reference==
==Reference==
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Drug-induced DNA repair: X-ray structure of a DNA-ditercalinium complex., Gao Q, Williams LD, Egli M, Rabinovich D, Chen SL, Quigley GJ, Rich A, Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2422-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2006181 2006181]
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Drug-induced DNA repair: X-ray structure of a DNA-ditercalinium complex., Gao Q, Williams LD, Egli M, Rabinovich D, Chen SL, Quigley GJ, Rich A, Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2422-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2006181 2006181]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Chen, S L.]]
[[Category: Chen, S L.]]
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[[Category: right handed dna]]
[[Category: right handed dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:12:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:32:12 2008''

Revision as of 08:32, 20 March 2008

Image:1d32.jpg


PDB ID 1d32

Drag the structure with the mouse to rotate
, resolution 1.700Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



DRUG-INDUCED DNA REPAIR: X-RAY STRUCTURE OF A DNA-DITERCALINIUM COMPLEX


Overview

Ditercalinium is a synthetic anticancer drug that binds to DNA by bis-intercalation and activates DNA repair processes. In prokaryotes, noncovalent DNA-ditercalinium complexes are incorrectly recognized by the uvrABC repair system as covalent lesions on DNA. In eukaryotes, mitochondrial DNA is degraded by excess and futile DNA repair. Using x-ray crystallography, we have determined, to 1.7 A resolution, the three-dimensional structure of a complex of ditercalinium bound to the double-stranded DNA fragment [d(CGCG)]2. The DNA in the complex with ditercalinium is kinked (by 15 degrees) and severely unwound (by 36 degrees) with exceptionally wide major and minor grooves. Recognition of the DNA-ditercalinium complex by uvrABC in prokaryotes, and by mitochondrial DNA repair systems in eukaryotes, might be related to drug-induced distortion of the DNA helix.

About this Structure

1D32 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Drug-induced DNA repair: X-ray structure of a DNA-ditercalinium complex., Gao Q, Williams LD, Egli M, Rabinovich D, Chen SL, Quigley GJ, Rich A, Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2422-6. PMID:2006181

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