1aoj

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[[Image:1aoj.png|left|200px]]
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==THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER==
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<StructureSection load='1aoj' size='340' side='right' caption='[[1aoj]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1aoj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1AOJ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aoj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aoj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1aoj RCSB], [http://www.ebi.ac.uk/pdbsum/1aoj PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ao/1aoj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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SH3 domains are structurally well-characterized as monomeric modular units of protein structure that mediate protein-protein recognition in numerous signal transduction proteins. The X-ray crystallographic structure of the Eps8 SH3 domain reveals a novel variation of the canonical SH3 fold: the SH3 domain from Eps8 is a dimer formed by strand interchange. In addition, co-immunoprecipitation experiments show that intact Eps8 is multimeric in vivo. Hence, the SH3 domain of Eps8 may represent a dimerization motif.
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{{STRUCTURE_1aoj| PDB=1aoj | SCENE= }}
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The SH3 domain of Eps8 exists as a novel intertwined dimer.,Kishan KV, Scita G, Wong WT, Di Fiore PP, Newcomer ME Nat Struct Biol. 1997 Sep;4(9):739-43. PMID:9303002<ref>PMID:9303002</ref>
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===THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_9303002}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1aoj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOJ OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:009303002</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Kishan, K V.R.]]
[[Category: Kishan, K V.R.]]

Revision as of 08:09, 30 July 2014

THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER

1aoj, resolution 2.50Å

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