Function
Uridine phosphorylase (UPP) catalyzes the conversion of uridine or deoxyuridine and phosphate to uracil and α-D-ribose 1-phosphate. UPP is part of RNA or DNA biosynthesis. Unhydrouridine is an inhibitor of UPP.
Disease
Relevance
Structural highlights
3D Structures of uridine phosphorylase
Updated on 30-July-2014
Uridine phosphorylase
1k3f, 1lx7, 1rxy, 1t0u – EcUPP – Escherichia coli
1ryz, 2iq5, 2oxf, 2qdk, 3dps – StUPP – Salmonella typhimurium
3o6v, 4k6o – VcUPP – Vibrio cholerae
4i2v – UPP – Yersinia pseudotuberculosis
Uridine phosphorylase binary complex
1sj9, 2hsw, 2i8a, 3ddo – StUPP + phosphate
1y1t – StUPP + sulfate
2oec, 3c74 – StUPP + inhibitor
3ku4 – bUPP + sulfate - bovine
4e1v – UPP + 5-fluorouracil – Salmonella enterica
4g8j – StUPP + 2’-deoxythymidine
4lnh – VfUPP + sulfate – Vibrio fischeri
4h1t – VcUPP + phosphate
4jp5 – UPP + sulfate – Yersinia pestis
4hen – SoUPP + sulfate – Shewanella oneidensis
Uridine phosphorylase ternary complex
1y1r, 1zl2, 2pga, 3fwp – StUPP + phosphate + inhibitor
2rj3 – StUPP + phosphate + uracil
1y1s – StUPP + sulfate + uracil
1y1q – StUPP + sulfate + UMP
1rxs – EcUPP + phosphate + 2’-deoxyuridine
3kuk – bUPP + sulfate + 2’-deoxyuridine
1rxu – EcUPP + phosphate + 2’-deoxythymidine
2hn9, 2hrd – StUPP + phosphate + thymine
2hwu – StUPP + phosphate + uridine
1tgy – EcUPP + ribose-1-phosphate + uracil
3qpb – UPP + ribose-1-phosphate + uracil – Streptococcus pyogenes
1u1c, 1u1d, 1u1e, 1u1f, 1u1g – EcUPP + phosphate + 5-substituted acyclouridine
1tgv – EcUPP + sulfate + 5-fluorouridine
3kvv – EcUPP + sulfate + 5-fluorouracil
3kvr – bUPP + sulfate + 5-fluorouracil
3kvy – bUPP + sulfate + uracil
3pns – VcUPP + sulfate + uracil
4mch – VfUPP + sulfate + hydroxyl naphthoic acid
4mci – VfUPP + sulfate + DMSO
4her – SoUPP + sulfate + uridine
1rxc – EcUPP + ribose-1-phosphate + phosphate + 5-fluorouracil + 5-fluorouridine
Human uridine phosphorylase
3eue – hUPP 1 + sulfate
3euf – hUPP 1 + benzylacyclouridine
3nbq – hUPP 1 + 5-fluorouracil
2xrf – hUPP 2 + uracil - human
3p0f – hUPP 2 + benzylacyclouridine
3p0e – hUPP 2 + phosphate + benzylacyclouridine
References