Adenosine deaminase
From Proteopedia
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| - | <StructureSection load='2pgf' size='350' side='right' caption='Structure of adenosine deaminase complex with Zn+2 and adenosine (PDB entry [[2pgf]])' scene=''> | + | <StructureSection load='2pgf' size='350' side='right' caption='Structure of adenosine deaminase complex with Zn+2 (grey), acetonitrile and adenosine (stick model) (PDB entry [[2pgf]])' scene=''> |
'''Adenosine deaminase''' (ADA) deaminates adenosine and deoxyadenosine into inosine or deoxyinosine. ADA is part of the purine metabolism. In humans ADA is involved in the development and maintenance of the immune system. ADA deficiency is the cause of severe combined immunodeficiency (SCID). SCID was the first disorder to be treated by gene therapy. There are 2 isoforms of ADA: ADA1 and ADA2. ADA contains Zn+2 ion in its active site. | '''Adenosine deaminase''' (ADA) deaminates adenosine and deoxyadenosine into inosine or deoxyinosine. ADA is part of the purine metabolism. In humans ADA is involved in the development and maintenance of the immune system. ADA deficiency is the cause of severe combined immunodeficiency (SCID). SCID was the first disorder to be treated by gene therapy. There are 2 isoforms of ADA: ADA1 and ADA2. ADA contains Zn+2 ion in its active site. | ||
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===Double-stranded RNA-specific adenosine deaminase=== | ===Double-stranded RNA-specific adenosine deaminase=== | ||
| - | [[1xmk]] – hADA<br /> | + | [[1xmk]] – hADA Zα domain <br /> |
| + | [[1qgp]] – hADA Zα domain - NMR<br /> | ||
| + | [[2l54]] – hADA Zα domain (mutant) - NMR<br /> | ||
| + | [[2mdr]] – hADA 3rd RNA-binding domain - NMR<br /> | ||
[[1zy7]] – hADA + inositol hexakisphosphate<br /> | [[1zy7]] – hADA + inositol hexakisphosphate<br /> | ||
| - | [[2acj]] – hADA + DNA<br /> | + | [[2acj]], [[1qbj]], [[2gxb]], [[3f21]], [[3f22]], [[3f23]], [[3irq]], [[3irr]] – hADA Zα domain + DNA<br /> |
[[2b7t]], [[2b7v]] – ADA – rat<br /> | [[2b7t]], [[2b7v]] – ADA – rat<br /> | ||
Revision as of 07:59, 31 July 2014
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