2mnz

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'''Unreleased structure'''
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==NMR Structure of KDM5B PHD1 finger in complex with H3K4me0(1-10aa)==
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<StructureSection load='2mnz' size='340' side='right' caption='[[2mnz]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2mnz]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MNZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MNZ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mny|1mny]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mnz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mnz RCSB], [http://www.ebi.ac.uk/pdbsum/2mnz PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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KDM5B is a histone H3K4me2/3 demethylase. The PHD1 domain of KDM5B is critical for demethylation, but the mechanism underlying the action of this domain is unclear. In this paper, we observed that PHD1KDM5B interacts with unmethylated H3K4me0. Our NMR structure of PHD1KDM5B in complex with H3K4me0 revealed that the binding mode is slightly different from that of other reported PHD fingers. The disruption of this interaction by double mutations on the residues in the interface (L325A/D328A) decreases the H3K4me2/3 demethylation activity of KDM5B in cells by approximately 50% and increases the transcriptional repression of tumor suppressor genes by approximately twofold. These findings imply that PHD1KDM5B may help maintain KDM5B at target genes to mediate the demethylation activities of KDM5B.
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The entry 2mnz is ON HOLD
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The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B.,Zhang Y, Yang H, Guo X, Rong N, Song Y, Xu Y, Lan W, Zhang X, Liu M, Xu Y, Cao C Protein Cell. 2014 Jun 22. PMID:24952722<ref>PMID:24952722</ref>
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Authors: Zhang, Y., Yang, H., Guo, X., Rong, N., Song, Y., Xu, Y., Lan, W., Xu, Y., Cao, C.
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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Description: NMR Structure of KDM5B PHD1 finger in complex with H3K4me0(1-10aa)
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Cao, C.]]
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[[Category: Guo, X.]]
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[[Category: Lan, W X.]]
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[[Category: Rong, N Y.]]
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[[Category: Song, Y J.]]
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[[Category: Xu, Y H.]]
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[[Category: Xu, Y W.]]
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[[Category: Yang, H R.]]
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[[Category: Zhang, Y.]]
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[[Category: Demethylase]]
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[[Category: H3k4]]
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[[Category: Kdm5b]]
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[[Category: Oxidoreductase]]
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[[Category: Phd1]]
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[[Category: Repression]]

Revision as of 02:24, 7 August 2014

NMR Structure of KDM5B PHD1 finger in complex with H3K4me0(1-10aa)

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