3we4
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of S6K1 kinase domain in complex with a pyrimidine derivative PF-4708671 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole== |
| - | + | <StructureSection load='3we4' size='340' side='right' caption='[[3we4]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3we4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WE4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WE4 FirstGlance]. <br> | |
| - | + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5FI:2-{[4-(5-ETHYLPYRIMIDIN-4-YL)PIPERAZIN-1-YL]METHYL}-5-(TRIFLUOROMETHYL)-1H-BENZIMIDAZOLE'>5FI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br> | |
| - | + | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | |
| - | + | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wf5|3wf5]], [[3wf6|3wf6]], [[3wf7|3wf7]], [[3wf8|3wf8]], [[3wf9|3wf9]]</td></tr> | |
| + | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3we4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3we4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3we4 RCSB], [http://www.ebi.ac.uk/pdbsum/3we4 PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Non-specific serine/threonine protein kinase]] | ||
| + | [[Category: Niwa, H.]] | ||
| + | [[Category: Shirouzu, M.]] | ||
| + | [[Category: Yokoyama, S.]] | ||
| + | [[Category: Atp-binding]] | ||
| + | [[Category: Phosphorylation]] | ||
| + | [[Category: Serine/threonine protein kinase domain]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
| + | [[Category: Zinc-binding]] | ||
Revision as of 02:36, 7 August 2014
Crystal structure of S6K1 kinase domain in complex with a pyrimidine derivative PF-4708671 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole
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