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4d08
From Proteopedia
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| - | ''' | + | ==PDE2a catalytic domain in complex with a brain penetrant inhibitor== |
| - | + | <StructureSection load='4d08' size='340' side='right' caption='[[4d08]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4d08]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D08 FirstGlance]. <br> | |
| - | + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=Q2T:1-(5-BUTOXYPYRIDIN-3-YL)-4-METHYL-8-(MORPHOLIN-4-YLMETHYL)[1,2,4]TRIAZOLO[4,3-A]QUINOXALINE'>Q2T</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br> | |
| - | + | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4d09|4d09]]</td></tr> | |
| - | + | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr> | |
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d08 RCSB], [http://www.ebi.ac.uk/pdbsum/4d08 PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: 3',5'-cyclic-nucleotide phosphodiesterase]] | ||
| + | [[Category: Andres, J I.]] | ||
| + | [[Category: Buijnsters, P.]] | ||
| + | [[Category: DeAngelis, M.]] | ||
| + | [[Category: Langlois, X.]] | ||
| + | [[Category: Rombouts, F.]] | ||
| + | [[Category: Sanderson, W.]] | ||
| + | [[Category: Trabanco, A.]] | ||
| + | [[Category: Tresadern, G.]] | ||
| + | [[Category: VanHoof, G.]] | ||
| + | [[Category: VanRoosbroeck, Y.]] | ||
| + | [[Category: Animal]] | ||
| + | [[Category: Binding site]] | ||
| + | [[Category: Catalytic domain]] | ||
| + | [[Category: Cyclic nucleotide phosphodiesterase]] | ||
| + | [[Category: Disease model]] | ||
| + | [[Category: Drug evaluation]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Phosphodiesterase 2 inhibitor]] | ||
| + | [[Category: Phosphodiesterase inhibitor]] | ||
| + | [[Category: Preclinical]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Structure-activity relationship]] | ||
| + | [[Category: Type 2]] | ||
| + | [[Category: Type 4]] | ||
Revision as of 02:38, 7 August 2014
PDE2a catalytic domain in complex with a brain penetrant inhibitor
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Categories: 3',5'-cyclic-nucleotide phosphodiesterase | Andres, J I. | Buijnsters, P. | DeAngelis, M. | Langlois, X. | Rombouts, F. | Sanderson, W. | Trabanco, A. | Tresadern, G. | VanHoof, G. | VanRoosbroeck, Y. | Animal | Binding site | Catalytic domain | Cyclic nucleotide phosphodiesterase | Disease model | Drug evaluation | Hydrolase | Phosphodiesterase 2 inhibitor | Phosphodiesterase inhibitor | Preclinical | Protein binding | Structure-activity relationship | Type 2 | Type 4
