Signal recognition particle protein
From Proteopedia
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| + | ===SRP=== | ||
[[1914]] – mSRP9/SRP14 – mouse<br /> | [[1914]] – mSRP9/SRP14 – mouse<br /> | ||
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| - | + | ===SRP complexes with RNA=== | |
[[1e8o]], [[1e8s]] - hSRP9 + hSRP14 + 7S RNA <br /> | [[1e8o]], [[1e8s]] - hSRP9 + hSRP14 + 7S RNA <br /> | ||
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[[2j37]] - hSRP19 + dSRP54 + ribosomal proteins L23, L31, L35 + RNA – wheat – EM<BR /> | [[2j37]] - hSRP19 + dSRP54 + ribosomal proteins L23, L31, L35 + RNA – wheat – EM<BR /> | ||
| - | + | ===Other SRP complexes=== | |
[[1jpj]], [[1jpn]], [[2c04]] – TaSRP54-like NG domain + GMPPNP<BR /> | [[1jpj]], [[1jpn]], [[2c04]] – TaSRP54-like NG domain + GMPPNP<BR /> | ||
Revision as of 08:02, 11 August 2014
Signal recognition particle (SRP) is a ribonucleoprotein which targets specific proteins to the endoplasmic reticulum (ER) in eukaryotes and the plasma membrane in prokaryotes. In eukaryotes SRP binds to the signal sequence of a newly synthesized polypeptide as it emerges from the ribosome. The binding allows for the coupling of the translation process to the translocation process. The SRP targets the nascent protein to the ER by docking into the SRP receptor. The eukaryotic SRP which has GTPase activity, is composed of SRP9, SRP14, SRP19, SRP54, SRP68, SRP72 and 7S RNA. The prokaryotic SRP is composed of FFH (SRP54-like) and 4.5S RNA.
Contents |
3D structures of SRP
Updated on 11-August-2014
SRP
1914 – mSRP9/SRP14 – mouse
1wgw – mSRP54 N terminal – NMR
1ls1, 2j45, 2j46, 1ffh, 1ng1, 3ng1 - TaSRP54-like NG domain – Thermus aquaticus
2ng1 - TaSRP54-like NG domain (mutant)
2ffh - TaSRP54-like residues 1-425 (mutant)
1kvn, 1kvv – SRP19 (mutant) – Archaeoglobus fulgidus – NMR
1qb2 – hSRP54
2hug – AtSRP43 chromo-2 domain + SRP54 M domain – Arabidopsis thaliana – NMR
3deo - AtSRP43 residues 85-267
3ui2 - AtSRP43 residues 84-327 + AtSRP54 RRKR motif
3dlu, 3dlv, 3dm5 – SRP19 – Pyrococcus furiosus
2w9j – SRP14 residues 1-91 – fission yeast
1j8m – AaSPR GTPase domain – Acicianus ambivalens
1j8y – AaSPR GTPase domain (mutant)
1qzx – SsSRP54 – Sulfolobus solfataricus
4p3f – hSRP68 (mutant) – human
SRP complexes with RNA
1e8o, 1e8s - hSRP9 + hSRP14 + 7S RNA
1ry1 - hSRP9 + hSRP14 + hSRP19 + hSRP54 + 7S RNA
1jid – hSRP19 + RNA
3ktv - hSRP19 + RNA S domain
3ktw - SsSRP19 + RNA S domain
1qzw – SsSRP + 7S RNA
1lng – MjSRP19 + RNA – Methanocaldococcus jannaschii
1l9a - MjSRP19 (mutant) + RNA
2v3c, 3ndb - MjSRP19 + MjSRP54 + 7S RNA
1mfq – hSRP19 + hSRP54 M domain + 7S RNA S domain
2iy3 – TaSRP54-like + RNA - EM
1dul, 1hq1, 2pxp – EcSRP54-like C terminal + RNA – Escherichia coli
3lqx - EcSRP54-like + RNA + Co-hexamine
2xkv - EcSRP54-like NG+M domains + 4.5SRNA – EM
2xxa - EcSRP54-like residues 1-433 (mutant) + cell division protein FtsY residues 196-497+ 4.5SRNA
3zn8 - EcSRP54 NG domain + cell division protein FtsY residues 201-495+ 4.5SRNA + dipeptidyl aminopeptidase B
2pxb, 2pxd, 2pxe, 2pxf, 2pxk, 2pxl, 2pxq, 2pxq, 2pxt, 2pxu, 2pxv - EcSRP54-like C terminal + 4.5SRNA domain IV (mutant)
2go5 – dSRP19 + SRP54 + hSRP receptor α subunit + mSRP receptor b subunit + ribosomal proteins L23, L31, L35 + RNA – dog
2j28 – EcSRP54-like + 70S ribosome – EM
2j37 - hSRP19 + dSRP54 + ribosomal proteins L23, L31, L35 + RNA – wheat – EM
Other SRP complexes
1jpj, 1jpn, 2c04 – TaSRP54-like NG domain + GMPPNP
1o87, 2c03 - TaSRP54-like NG domain + GDP
1okk, 1rj9, 2cnw - TaSRP54-like NG domain + cell division protein FTSY
2j7p - TaSRP54-like NG domain + cell division protein FTSY + GMPPNP
3dep - AtSRP43 residues 85-267 + polypeptide
3kl4 – SsSRP54 residues 2-432 + polypeptide
4c7o – EcSRP + FTSY + SRP RNA
