This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Cyclin-dependent kinase
From Proteopedia
| Line 14: | Line 14: | ||
| - | + | ===CDK3=== | |
[[1fpz]] – hCDK3 (mutant) | [[1fpz]] – hCDK3 (mutant) | ||
| Line 20: | Line 20: | ||
'''CDK4 [[Cyclin Dependent Kinase-4]]''' | '''CDK4 [[Cyclin Dependent Kinase-4]]''' | ||
| - | + | ===CDK5=== | |
[[1h4l]] – hCDK5 + CDK5 activator<br /> | [[1h4l]] – hCDK5 + CDK5 activator<br /> | ||
| Line 26: | Line 26: | ||
[[3o0g]] - hCDK5 + ATP analog + CDK5 activator<br /> | [[3o0g]] - hCDK5 + ATP analog + CDK5 activator<br /> | ||
| - | + | ===CDK6=== | |
[[1bi7]] – hCDK6 + multiple tumor suppressor<br /> | [[1bi7]] – hCDK6 + multiple tumor suppressor<br /> | ||
| Line 32: | Line 32: | ||
[[1g3n]] – hCDK6 + cyclin D homolog + CDK protein inhibitor<br /> | [[1g3n]] – hCDK6 + cyclin D homolog + CDK protein inhibitor<br /> | ||
| - | + | ===CDK7=== | |
[[1ua2]] – hCDK7<br /> | [[1ua2]] – hCDK7<br /> | ||
| - | + | ===CDK8=== | |
[[3rgf]] – hCDK8 + cyclin C + inhibitor<br /> | [[3rgf]] – hCDK8 + cyclin C + inhibitor<br /> | ||
| - | + | ===CDK9=== | |
[[3blh]], [[4ec8]], [[4ec9]] – hCDK9-P + cyclin T1 (mutant)<br /> | [[3blh]], [[4ec8]], [[4ec9]] – hCDK9-P + cyclin T1 (mutant)<br /> | ||
| Line 49: | Line 49: | ||
[[4imy]] – hCDK9-P + cyclin T1 + CDK9 elongation factor-associated protein<br /> | [[4imy]] – hCDK9-P + cyclin T1 + CDK9 elongation factor-associated protein<br /> | ||
| - | + | ===CDK12=== | |
[[4cjy]] – hCDK12-P + cyclin K<br /> | [[4cjy]] – hCDK12-P + cyclin K<br /> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:06, 11 August 2014
Template:STRUCTURE 3rgf Cyclin-dependent kinase (CDK) are serine/threonine kinases which are important to the regulation of the cell cycle. CDKs are small proteins which contain just a kinase domain. In order to function, CDK binds the regulatory protein cyclin. CDKs phosphorylate their substrates at a consensus tetrapeptide. The CDK classes differ by the binding cyclin and their function in human. For details on CDK2 see Cell Division Protein Kinase 2. CDK3 binds cyclin C and functions during the G1 phase. For details on CDK4 see Cyclin Dependent Kinase-4. CDK5 binds p53 and functions during transcription. CDK6 binds cyclin D and functions during the G1 phase. CDK8 binds cyclin C and functions during transcription. CDK9 facilitates the transition from abortive to productive transcription elongation by phosphorylating the C-terminal domain of the large subunit of RNA polymerase. CDK12 is required for RNA splicing.
Contents |
3D structures of cyclin-dependent kinase
Updated on 11-August-2014
CDK2 Cell Division Protein Kinase 2
CDK3
1fpz – hCDK3 (mutant)
CDK4 Cyclin Dependent Kinase-4
CDK5
1h4l – hCDK5 + CDK5 activator
1ung, 1unh, 1unl - hCDK5 (mutant) + CDK5 activator + inhibitor
3o0g - hCDK5 + ATP analog + CDK5 activator
CDK6
1bi7 – hCDK6 + multiple tumor suppressor
1bi8, 1blx – hCDK6 + CDK protein inhibitor
1g3n – hCDK6 + cyclin D homolog + CDK protein inhibitor
CDK7
1ua2 – hCDK7
CDK8
3rgf – hCDK8 + cyclin C + inhibitor
CDK9
3blh, 4ec8, 4ec9 – hCDK9-P + cyclin T1 (mutant)
3blq – hCDK9-P + cyclin T1 (mutant) + ATP
3lq5, 3my1, 3tn8, 3tnh, 3tni, 4bcf, 4bcg, 4bch, 4bci, 4bcj – hCDK9-P + cyclin T1 (mutant) + inhibitor
3blr – hCDK9-P + cyclin T1 + flavopiridol
3mi9, 3mia – hCDK9-P + cyclin T1 + HIV-1 TAT
4imy – hCDK9-P + cyclin T1 + CDK9 elongation factor-associated protein
CDK12
4cjy – hCDK12-P + cyclin K
