4fwg
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of the Lon-like protease MtaLonC in complex with lactacystin== | |
| - | + | <StructureSection load='4fwg' size='340' side='right' caption='[[4fwg]], [[Resolution|resolution]] 1.99Å' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4fwg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_baa-399 Atcc baa-399]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FWG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FWG FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SLA:OMURALIDE,+OPEN+FORM'>SLA</scene><br> | ||
| + | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4fw9|4fw9]], [[4fwd|4fwd]], [[4fwh|4fwh]]</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_La Endopeptidase La], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.53 3.4.21.53] </span></td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fwg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fwg RCSB], [http://www.ebi.ac.uk/pdbsum/4fwg PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The Lon proteases are a unique family of chambered proteases with a built-in AAA+ (ATPases associated with diverse cellular activities) module. Here, crystal structures of a unique member of the Lon family with no intrinsic ATPase activity in the proteolytically active form are reported both alone and in complexes with three covalent inhibitors: two peptidomimetics and one derived from a natural product. This work reveals the unique architectural features of an ATP-independent Lon that selectively degrades unfolded protein substrates. Importantly, these results provide mechanistic insights into the recognition of inhibitors and polypeptide substrates within the conserved proteolytic chamber, which may aid the development of specific Lon-protease inhibitors. | ||
| - | + | Structures of an ATP-independent Lon-like protease and its complexes with covalent inhibitors.,Liao JH, Ihara K, Kuo CI, Huang KF, Wakatsuki S, Wu SH, Chang CI Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1395-402. doi:, 10.1107/S0907444913008214. Epub 2013 Jul 13. PMID:23897463<ref>PMID:23897463</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Atcc baa-399]] | ||
[[Category: Endopeptidase La]] | [[Category: Endopeptidase La]] | ||
| - | [[Category: Meiothermus taiwanensis]] | ||
[[Category: Chang, C I.]] | [[Category: Chang, C I.]] | ||
[[Category: Huang, K F.]] | [[Category: Huang, K F.]] | ||
Revision as of 06:33, 13 August 2014
Crystal structure of the Lon-like protease MtaLonC in complex with lactacystin
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