2cju

From Proteopedia

Revision as of 15:05, 30 October 2007

CRYSTAL STRUCTURE OF THE TEPC15-VK45.1 ANTI-2-PHENYL-5-OXAZOLONE NQ16-113.8 SCFV IN COMPLEX WITH PHOXGABA

Overview

Affinity maturation is a process that leads to the emergence of more, efficient antibodies following initial antigen encounter and represents a, key strategy of the adaptive immunity of vertebrate organisms. Earlier and, detailed sequence studies of the antibody response to a model antigen, the, hapten 2-phenyl-5-oxazolone (phOx), define three different classes of, antibodies. Class I antibodies use the V(H)Ox1/V(kappa)Ox1 gene pair and, dominate the early stages of the anti-phOx response, class II antibodies, use the V(kappa)Ox1 gene but a different V(H) segment and are common in, the intermediate stages, and class III antibodies use the, TEPC15/V(kappa)45.1 genes and play the greatest role in the late stages., Only the crystal structure of one anti-phOx antibody, the class II, NQ10/12.5 ... [(full description)]

About this Structure

2CJU is a [Single protein] structure of sequence from [Mus musculus] with PHX as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Structural basis of affinity maturation of the TEPC15/Vkappa45.1 anti-2-phenyl-5-oxazolone antibodies., Scotti C, Gherardi E, J Mol Biol. 2006 Jun 23;359(5):1161-9. Epub 2006 May 2. PMID:16682055

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