2mow
From Proteopedia
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| - | ''' | + | ==Structure of Nrd1p CID - Trf4p NIM complex== |
| + | <StructureSection load='2mow' size='340' side='right' caption='[[2mow]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2mow]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MOW FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mow OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mow RCSB], [http://www.ebi.ac.uk/pdbsum/2mow PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The Nrd1-Nab3-Sen1 (NNS) complex is essential for controlling pervasive transcription and generating sn/snoRNAs in S. cerevisiae. The NNS complex terminates transcription of noncoding RNA genes and promotes exosome-dependent processing/degradation of the released transcripts. The Trf4-Air2-Mtr4 (TRAMP) complex polyadenylates NNS target RNAs and favors their degradation. NNS-dependent termination and degradation are coupled, but the mechanism underlying this coupling remains enigmatic. Here we provide structural and functional evidence demonstrating that the same domain of Nrd1p interacts with RNA polymerase II and Trf4p in a mutually exclusive manner, thus defining two alternative forms of the NNS complex, one involved in termination and the other in degradation. We show that the Nrd1-Trf4 interaction is required for optimal exosome activity in vivo and for the stimulation of polyadenylation of NNS targets by TRAMP in vitro. We propose that transcription termination and RNA degradation are coordinated by switching between two alternative partners of the NNS complex. | ||
| - | + | Molecular Basis for Coordinating Transcription Termination with Noncoding RNA Degradation.,Tudek A, Porrua O, Kabzinski T, Lidschreiber M, Kubicek K, Fortova A, Lacroute F, Vanacova S, Cramer P, Stefl R, Libri D Mol Cell. 2014 Aug 7;55(3):467-481. doi: 10.1016/j.molcel.2014.05.031. Epub 2014 , Jul 24. PMID:25066235<ref>PMID:25066235</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Kabzinski, T.]] | ||
| + | [[Category: Kubicek, K.]] | ||
| + | [[Category: Stefl, R.]] | ||
| + | [[Category: Protein-protein interaction]] | ||
| + | [[Category: Rna degradation]] | ||
| + | [[Category: Rnap ii ctd]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Transcription termination]] | ||
Revision as of 09:00, 13 August 2014
Structure of Nrd1p CID - Trf4p NIM complex
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