1dj8

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[[Image:1dj8.jpg|left|200px]]<br /><applet load="1dj8" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1dj8.jpg|left|200px]]
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caption="1dj8, resolution 2.0&Aring;" />
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'''CRYSTAL STRUCTURE OF E. COLI PERIPLASMIC PROTEIN HDEA'''<br />
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{{Structure
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|PDB= 1dj8 |SIZE=350|CAPTION= <scene name='initialview01'>1dj8</scene>, resolution 2.0&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF E. COLI PERIPLASMIC PROTEIN HDEA'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1DJ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DJ8 OCA].
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1DJ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DJ8 OCA].
==Reference==
==Reference==
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HDEA, a periplasmic protein that supports acid resistance in pathogenic enteric bacteria., Gajiwala KS, Burley SK, J Mol Biol. 2000 Jan 21;295(3):605-12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10623550 10623550]
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HDEA, a periplasmic protein that supports acid resistance in pathogenic enteric bacteria., Gajiwala KS, Burley SK, J Mol Biol. 2000 Jan 21;295(3):605-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10623550 10623550]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: alpha helical]]
[[Category: alpha helical]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:17:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:39:21 2008''

Revision as of 08:39, 20 March 2008

Image:1dj8.jpg


PDB ID 1dj8

Drag the structure with the mouse to rotate
, resolution 2.0Å
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF E. COLI PERIPLASMIC PROTEIN HDEA


Overview

The X-ray crystal structure of the Escherichia coli stress response protein HDEA has been determined at 2.0 A resolution. The single domain alpha-helical protein is found in the periplasmic space, where it supports an acid resistance phenotype essential for infectivity of enteric bacterial pathogens, such as Shigella and E. coli. Functional studies demonstrate that HDEA is activated by a dimer-to-monomer transition at acidic pH, leading to suppression of aggregation by acid-denatured proteins. We suggest that HDEA may support chaperone-like functions during the extremely acidic conditions.

About this Structure

1DJ8 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

HDEA, a periplasmic protein that supports acid resistance in pathogenic enteric bacteria., Gajiwala KS, Burley SK, J Mol Biol. 2000 Jan 21;295(3):605-12. PMID:10623550

Page seeded by OCA on Thu Mar 20 10:39:21 2008

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