1bqf
From Proteopedia
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| - | [[ | + | ==GROWTH-BLOCKING PEPTIDE (GBP) FROM PSEUDALETIA SEPARATA== |
| + | <StructureSection load='1bqf' size='340' side='right' caption='[[1bqf]], [[NMR_Ensembles_of_Models | 16 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1bqf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Apanteles_kariyai Apanteles kariyai]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BQF FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bqf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1bqf RCSB], [http://www.ebi.ac.uk/pdbsum/1bqf PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Growth-blocking peptide (GBP) is an insect growth factor consisting of 25 amino acid residues that retards the development of lepidopteran larvae at high concentration while it stimulates larval growth at low concentration. In this study, we determined the solution structure of GBP by two-dimensional 1H NMR spectroscopy. The structure contains a short segment of double-stranded beta-sheet involving residues 11-13 and 19-21 and a type-II beta-turn in the loop region (residues 8-11), whereas the N and C termini are disordered. This is the first report of the three-dimensional structure of the peptiderigic insect growth factor, and the structure of the well defined region of GBP was found to share similarity with that of the C-terminal domain of the epidermal growth factor (EGF). Because GBP has been reported to stimulate DNA synthesis of not only insect cells but also human keratinocyte cells at the same level with EGF, the structural similarity between GBP and EGF may lead to the interaction of GBP to EGF receptor. | ||
| - | + | Solution structure of an insect growth factor, growth-blocking peptide.,Aizawa T, Fujitani N, Hayakawa Y, Ohnishi A, Ohkubo T, Kumaki Y, Kawano K, Hikichi K, Nitta K J Biol Chem. 1999 Jan 22;274(4):1887-90. PMID:9890941<ref>PMID:9890941</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | == | + | __TOC__ |
| - | + | </StructureSection> | |
[[Category: Apanteles kariyai]] | [[Category: Apanteles kariyai]] | ||
[[Category: Aizawa, T.]] | [[Category: Aizawa, T.]] | ||
Revision as of 09:34, 13 August 2014
GROWTH-BLOCKING PEPTIDE (GBP) FROM PSEUDALETIA SEPARATA
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