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1dll

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[[Image:1dll.gif|left|200px]]<br /><applet load="1dll" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1dll.gif|left|200px]]
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caption="1dll, resolution 1.8&Aring;" />
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'''THE HC FRAGEMENT OF TETANUS TOXIN COMPLEXED WITH LACTOSE'''<br />
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{{Structure
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|PDB= 1dll |SIZE=350|CAPTION= <scene name='initialview01'>1dll</scene>, resolution 1.8&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=LAT:LACTOSE'>LAT</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68]
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|GENE=
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}}
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'''THE HC FRAGEMENT OF TETANUS TOXIN COMPLEXED WITH LACTOSE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1DLL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani] with <scene name='pdbligand=LAT:'>LAT</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLL OCA].
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1DLL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLL OCA].
==Reference==
==Reference==
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The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding., Emsley P, Fotinou C, Black I, Fairweather NF, Charles IG, Watts C, Hewitt E, Isaacs NW, J Biol Chem. 2000 Mar 24;275(12):8889-94. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10722735 10722735]
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The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding., Emsley P, Fotinou C, Black I, Fairweather NF, Charles IG, Watts C, Hewitt E, Isaacs NW, J Biol Chem. 2000 Mar 24;275(12):8889-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10722735 10722735]
[[Category: Clostridium tetani]]
[[Category: Clostridium tetani]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: jelly roll]]
[[Category: jelly roll]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:17:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:40:27 2008''

Revision as of 08:40, 20 March 2008

Image:1dll.gif


PDB ID 1dll

Drag the structure with the mouse to rotate
, resolution 1.8Å
Ligands: and
Activity: Tentoxilysin, with EC number 3.4.24.68
Coordinates: save as pdb, mmCIF, xml



THE HC FRAGEMENT OF TETANUS TOXIN COMPLEXED WITH LACTOSE


Overview

The entry of tetanus neurotoxin into neuronal cells proceeds through the initial binding of the toxin to gangliosides on the cell surface. The carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin contains the ganglioside-binding site, which has not yet been fully characterized. The crystal structures of native H(C) and of H(C) soaked with carbohydrates reveal a number of binding sites and provide insight into the possible mode of ganglioside binding.

About this Structure

1DLL is a Single protein structure of sequence from Clostridium tetani. Full crystallographic information is available from OCA.

Reference

The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding., Emsley P, Fotinou C, Black I, Fairweather NF, Charles IG, Watts C, Hewitt E, Isaacs NW, J Biol Chem. 2000 Mar 24;275(12):8889-94. PMID:10722735

Page seeded by OCA on Thu Mar 20 10:40:27 2008

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