Geranylgeranyl transferase

Function

Geranylgeranyl transferase type 1 (GGT1) adds a 20-carbon isoprenoid group called geranylgeranyl (GG) to the C-terminal of proteins containg the CAAX motif (Cysteine, Aliphatic, Aliphatic, any amino acid). Geranylgeranyl transferase type 2 (GGT2) adds 2 GG groups to C-terminal cysteine residue of a protein. The addition of the hydrophobic prenyl group causes the proteins to become membrane-associated.

Disease

Relevance

Structural highlights

3D structures of eranylgeranyl transferase

Updated on 14-August-2014

1dce – rGGT α+β subunits – rat

3dss – rGGT type 2 α+β subunits

Geranylgeranyl transferase complex

3c72, 3pz1, 3pz3, 4ehm, 4gts, 4gtt, 4gtv – rGGT type 2 α+β subunits + inhibitor
3hxb, 3hxc, 3hxd, 3hxe, 3hxf – rGGT type 2 α (mutant) +β subunits + inhibitor
1ltx – rGGT α+β subunits + tetra-alanine + Rab escort protein + farnesyl
3dst – rGGT type 2 α+β subunits + GG-pyrophosphate
3dsu – rGGT type 2 α+β subunits + farnesyl-pyrophosphate
3dsv, 3dsw, 3dsx – rGGT type 2 α+β subunits + GG
3pz2 – rGGT type 2 α+β subunits + GG-pyrophosphate + inhibitor

References