Adaptin

Adaptin (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The AP complex is a hetertetramer composed of 2 large AP: AP-α or AP-γ and AP-β, a medium-size AP: AP-μ and small AP: AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals.

3D structures of adaptin

Updated on 14-August-2014

AP-α-2

1b9x, 1qts – mAP appendage domain – mouse
1qtp – mAP appendage domain (mutant)
1ky6, 1kyd – mAP appendage domain + epsin peptide
1ky7 – mAP appendage domain + amphiphysin peptide
1kyf, 1kyu – mAP appendage domain + eps15 peptide
1w80, 2vj0 – mAP appendage domain + synaptojanin peptide
3hs8 – mAP appendage domain + intersectin peptide

AP-β

1e42 – hAP-1 appendage domain - human
2g30 – hAP-1 appendage domain + ARH peptide
3h1z – hAP-1 appendage domain + PTDINSPKI-γ peptide
3hs9 – hAP-1 appendage domain + intersectin peptide
2iv9 – hAP-2 appendage domain + eps15 peptide
2iv8 – hAP-2 appendage domain + B-arrestin peptide

AP-γ

1iu1 – hAP-1 ear domain
1gyu, 2a7b – mAP-1 appendage domain
1gyv, 1gyw, 3zy7 – mAP-1 appendage domain (mutant)
2e9g, 4bcx – hAP-2 ear domain
2ymt – hAP-2 ear domain + peptide
3zhf – hAP-2 ear domain + large envelope protein peptide

AP-δ-1

4afi – hAP-1/vesicle-associated membrane protein 7

AP-μ

3h85 – rAP-1 appendage domain + PTDINSPKIγ peptide
4emz, 4en2 – mAP-1 sorting motif recognition domain + nef + MHC-I
1bw8, 1i31 – rAP-2 + EGFR peptide
1bxx – rAP-2 + TGN38 peptide
1hes – rAP-2 + selectin peptide
2bp5 – rAP-2 + purinoceptor peptide
2pr9 – rAP-2 + GABA receptor peptide

AP-α + AP-β + AP-μ + AP-σ

2vgl – rAPα-2 + APβ-1 + APμ-1 + APσ-1
2jkr, 2jkt – mAPα-2 + APβ-1 + APμ-1 + APσ-1 + CD4 peptide
2xa7 – rAPα-2 + APβ + APμ + APσ + cargo peptide

AP-γ + AP-β + AP-μ + AP-σ

1w63 – mAPγ-1 + APβ-1 + APμ-1 + APσ-1A
4hmy – mAPγ-1 + APβ-1 + APμ-1 + APσ-3 + ADP-ribosylation factor