Arginine repressor

Arginine repressor (ArgR) is a prokaryotic repressor which regulates the arginine deiminase pathway. In this pathway, arginine is metabolized to form ammonia, CO2 and ATP. The ArgR releases the expression of the arginine deiminase pathway in the presence of arginine. The genes controlled by ArgR are not found in a single operon. While repressors are usually active as dimers, ArgR is a hexamer and binds to 2 palindromic DNA sites. The structure of ArgR shows a DNA-binding domain at the N-terminal and a C-terminal domain which contains the intersubunit interaction sites and the Arg binding site.

3D structures of arginine repressor

Updated on 14-August-2014

Arginine repressor

1b4a – GsArgR – Geobacillus stearothermophilus
1f9n – BsArgR – Bacillus subtilis
3v4g – ArgR – Vibrio vulnificus
3ere – MtArgR + DNA – Mycobacterium tuberculosis
3fhz, 3laj – MtArgR + DNA + Arg
3lap – MtArgR + DNA + canavanine

Arginine repressor N terminal

1aoy – EcArgR N terminal - Escherichia coli - NMR
1b4b – BsArgR N terminal
2p5l – BsArgR N terminal + DNA

Arginine repressor C terminal

1xxc – EcArgR C terminal
2p5k – GsArgR C terminal
3bue – MtArgR C terminal
1xxb – EcArgR C terminal + Arg
1xxa, 1xxb – EcArgR C terminal + Arg
2p5m – BsArgR C terminal (mutant) + Arg
2zfz, 3cag – MtArgR C terminal + Arg