Casein kinase
From Proteopedia
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{{STRUCTURE_3mb6| PDB=3mb6 | SIZE=400| SCENE= |right|CAPTION=Human casein kinase catalytic subunit complex with difurane derivative inhibitor and sulfate ion, [[3mb6]] }} | {{STRUCTURE_3mb6| PDB=3mb6 | SIZE=400| SCENE= |right|CAPTION=Human casein kinase catalytic subunit complex with difurane derivative inhibitor and sulfate ion, [[3mb6]] }} | ||
| - | '''Casein kinase''' (CK) is a protein kinase which functions as regulators of signal transduction. CK1 is a serine/threonine kinase with several members: α, β1, γ1, γ2, γ3, δ and ε. CK2 functions in cell cycle control, DNA repair and circadian rhythm regulation. CK2 is a tetramer with a pair of 2 subunits – the α subunit is the catalytic one and the β subunit is the regulatory one. | + | '''Casein kinase''' (CK) is a protein kinase which functions as regulators of signal transduction. '''CK1''' is a serine/threonine kinase with several members: α, β1, γ1, γ2, γ3, δ and ε. '''CK2''' functions in cell cycle control, DNA repair and circadian rhythm regulation. CK2 is a tetramer with a pair of 2 subunits – the α subunit is the catalytic one and the β subunit is the regulatory one. |
| - | __NOTOC__ | ||
== 3D Structures of casein kinase == | == 3D Structures of casein kinase == | ||
Revision as of 06:55, 17 August 2014
Casein kinase (CK) is a protein kinase which functions as regulators of signal transduction. CK1 is a serine/threonine kinase with several members: α, β1, γ1, γ2, γ3, δ and ε. CK2 functions in cell cycle control, DNA repair and circadian rhythm regulation. CK2 is a tetramer with a pair of 2 subunits – the α subunit is the catalytic one and the β subunit is the regulatory one.
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3D Structures of casein kinase
Updated on 17-August-2014
CK1
2c47 – hCK1-γ2 – human
2chl - hCK1-γ3
2cmw – hCK1-γ1 + inhibitor
2izr, 2izs, 2izs, 2izu, 2izt, 4g16, 4g17, 4hgl, 4hgs - hCK1-γ3 + inhibitor
3uys – hCK1-δ
3uyt, 3uzp, 4hgt, 4hnf, 4kb8, 4kba, 4kbc, 4kbk – hCK1-δ + inhibitor
1cki – rCK1-δ (mutant) – rat
1ckj - rCK1-δ (mutant) + WO4
4jjr - CK1-δ - mouse
4hok - hCK1-ε
4hni - hCK1-ε + inhibitor
1csn – yCK1 + MgATP – fission yeast
2csn, 1eh4 – yCK1 catalytic domain + inhibitor
CK2 catalytic subunit
1pjk, 3at2, 3q04, 3qa0, 3war - hCK2 α subunit
1na7, 3fwq, 3juh - hCK2 α subunit (mutant)
3axw, 3r0t, 3u4u – hCK2 α subunit + inhibitor
3u87 – hCK2 α subunit + ATP analog
3q9w, 3q9x – hCK2 α subunit + emodin
3q9y, 3q9z – hCK2 α subunit + quinalizarin
3u9c – hCK2 α subunit + resorufin
3ofm - hCK2 α’ subunit
2r7i - rCK2 α subunit
1lpu, 1lr4, 1jam - mCK2 α subunit
1daw, 1day – mCK2 + Mg-AMPPNP
1f0q, 3pzh – mCK2 α subunit + emodin
1zoe, 1zog, 1zoh – mCK2 α subunit + TBB derivative
CK2 catalytic subunit binary complex
2pvr - hCK2 α subunit + sulfate
3rp0 – hCK2 α subunit + α’ subunit + ATP analog
3bqc, 3c13 - hCK2 α subunit + emodin
1j91 - mCK2 α subunit + ATP competitive inhibitor - maize
1lp4 - mCK2 α subunit + Mg-AMPPNP
3nsz - hCK2 α subunit + AMPPN
3w8l - hCK2 α subunit (mutant) + inositol hexakisphosphate
4dgm - mCK2 α subunit + apigenin
4dgn - mCK2 α subunit + luteolin
4dgo - mCK2 α subunit + tyrphostin
1m2p, 1m2q, 1m2r, 1om1, 2oxd, 2oxx, 2oxy, 2qc6, 2pvh, 3fl5, 3kxg, 3kxh, 3kxm, 3kxn, 3pvg, 3pwd - mCK2 α subunit + inhibitor
3e3b, 2zjw, 3h30, 3mb6, 3mb7, 3nga, 3rps, 3pe1, 3pe2, 3amy, 3at3, 3at4, 4anm, 4grb, 4gub - hCK2 α subunit + inhibitor
4fbx - hCK2 α subunit + polypeptide inhibitor
4ib5 - hCK2 α subunit + hCK2 β polypeptide
2pvh, 2pvj, 2pvk, 2pvl, 2pvm, 2pvn, 3be9 - mCK2 α subunit (mutant) + inhibitor
4fi1, 4mwh - yCK2 α subunit + ATP
CK2 regulatory subunit
2r6m - rCK2 β subunit
1rqf - CK2 β subunit + cyclin-dependent kinase peptide – Xenopus laevis
CK2 catalytic + regulatory subunits
1jwh, 4md7 - hCK2 α subunit + β subunit
4dgl, 4md8, 4md9 - hCK2 α subunit (mutant) + β subunit
1ds5 - mCK2 α subunit + β subunit peptide
