Dihydropteroate synthase
From Proteopedia
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| + | ===DHPS=== | ||
[[1ad1]], [[4hb7]] – SaDHPS - ''Staphylococcus aureus'' <br /> | [[1ad1]], [[4hb7]] – SaDHPS - ''Staphylococcus aureus'' <br /> | ||
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[[3tzn]] – YpDHPS – ''Yersinia pestis'' | [[3tzn]] – YpDHPS – ''Yersinia pestis'' | ||
| - | + | ===DHPS binary complexes=== | |
[[1ad4]] – SaDHPS + pterin-pyrophosphate<br /> | [[1ad4]] – SaDHPS + pterin-pyrophosphate<br /> | ||
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[[3tyu]] – YpDHPS + pteroic acid | [[3tyu]] – YpDHPS + pteroic acid | ||
| - | + | ===DHPS ternary complexes=== | |
[[1aj0]] – EcDHPS + sulfanilamide + amino-methyldiene-dihydro-pteridinone<br /> | [[1aj0]] – EcDHPS + sulfanilamide + amino-methyldiene-dihydro-pteridinone<br /> | ||
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[[3tzf]] - YpDHPS + sulfa derivative + hydroxymethylpterin-diphosphate<br /> | [[3tzf]] - YpDHPS + sulfa derivative + hydroxymethylpterin-diphosphate<br /> | ||
| - | + | ===Bifunctional 6-hydroxymethyl-7,8-dihydropterin pyrophsphokinase-DHPS=== | |
[[3mcm]], [[3mcn]] – FtPPPK-DHPS – ''Francisella tulerensis''<br /> | [[3mcm]], [[3mcn]] – FtPPPK-DHPS – ''Francisella tulerensis''<br /> | ||
Revision as of 10:29, 17 August 2014
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3S structures of dihydropteroate synthase
Updated on 17-August-2014
DHPS
1ad1, 4hb7 – SaDHPS - Staphylococcus aureus
1ajz – EcDHPS – Escherichia coli
1tws, 3v5o – BaDHPS – Bacillus anthracis
2dqw - TtDHPS – Thermus thermophilus
2vef - SpDHPS – Streptococcus pneumonia
2vp8 – MtDHPS – Mycobacterium tuberculosis
2y5j – BcDHPS – Burkholderia cenocepacia
3tzn – YpDHPS – Yersinia pestis
DHPS binary complexes
1ad4 – SaDHPS + pterin-pyrophosphate
1aj2 – EcDHPS + dihydro-pterin-methanyl-phosphonophosphate
1eye - MtDHPS + pterin-methyl-phosphate
1tww - BaDHPS + hydroxymethylpterin-diphosphate
1twz - BaDHPS + pterin-methyl-phosphate
1tx0 - BaDHPS + pteroic acid
1tx2, 3h21, 3h22, 3h23, 3h24, 3h26, 3h2a, 3h2c, 3h2e, 3h2f, 3h2m, 3h2n, 3h2o, 4d8z, 4d9p, 4dai, 4db7, 4d8a, 4daf - BaDHPS + inhibitor
2dza - TtDHPS + PABA
2dzb - TtDHPS + hydroxymethylpterin-diphosphate
2veg - SpDHPS + pterin-methyl-phosphate
2y5s - BcDHPS + dihydro-pteroate
3tya - BaDHPS + dihydro-pteroate
3tyc - BaDHPS + amino-hydroxymethyl-dihydro-pteridinone
3tr9 - DHPS + pteroic acid – Coxiella burnetii
3tyu – YpDHPS + pteroic acid
DHPS ternary complexes
1aj0 – EcDHPS + sulfanilamide + amino-methyldiene-dihydro-pteridinone
3tyb - BaDHPS + hydroxybenzoic acid + amino-hydroxymethyl-dihydro-pteridinone
3tyd - BaDHPS + pyrophosphate+ amino-hydroxymethyl-dihydro-pteridinone
3tye - BaDHPS + sulfa derivative + amino-hydroxymethyl-dihydro-pteridinone
3tyz - YpDHPS + pyrophosphate + PABA + amino-hydroxymethyl-dihydro-pteridinone
3tzf - YpDHPS + sulfa derivative + hydroxymethylpterin-diphosphate
Bifunctional 6-hydroxymethyl-7,8-dihydropterin pyrophsphokinase-DHPS
3mcm, 3mcn – FtPPPK-DHPS – Francisella tulerensis
3mco - FtPPPK-DHPS + amino-hydroxymethyl-dihydro-pteridinone + methyladenosine triphosphate
2bmb - PPPK-DHPS + pterin-methyl-phosphate - yeast
References
- ↑ Chu WT, Zhang JL, Zheng QC, Chen L, Xue Q, Zhang HX. Insights into the drug resistance induced by the BaDHPS mutations: molecular dynamic simulations and MM/GBSA studies. J Biomol Struct Dyn. 2012 Oct 2. PMID:23030549 doi:10.1080/07391102.2012.726529
