We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1dn1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1dn1.jpg|left|200px]]<br /><applet load="1dn1" size="350" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1dn1.jpg|left|200px]]
-
caption="1dn1, resolution 2.60&Aring;" />
+
 
-
'''CRYSTAL STRUCTURE OF THE NEURONAL-SEC1/SYNTAXIN 1A COMPLEX'''<br />
+
{{Structure
 +
|PDB= 1dn1 |SIZE=350|CAPTION= <scene name='initialview01'>1dn1</scene>, resolution 2.60&Aring;
 +
|SITE=
 +
|LIGAND=
 +
|ACTIVITY=
 +
|GENE=
 +
}}
 +
 
 +
'''CRYSTAL STRUCTURE OF THE NEURONAL-SEC1/SYNTAXIN 1A COMPLEX'''
 +
 
==Overview==
==Overview==
Line 7: Line 16:
==About this Structure==
==About this Structure==
-
1DN1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DN1 OCA].
+
1DN1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DN1 OCA].
==Reference==
==Reference==
-
Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex., Misura KM, Scheller RH, Weis WI, Nature. 2000 Mar 23;404(6776):355-62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10746715 10746715]
+
Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex., Misura KM, Scheller RH, Weis WI, Nature. 2000 Mar 23;404(6776):355-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10746715 10746715]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
Line 19: Line 28:
[[Category: protein-protein complex]]
[[Category: protein-protein complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:18:19 2008''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:41:07 2008''

Revision as of 08:41, 20 March 2008

Image:1dn1.jpg


PDB ID 1dn1

Drag the structure with the mouse to rotate
, resolution 2.60Å
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF THE NEURONAL-SEC1/SYNTAXIN 1A COMPLEX


Overview

Syntaxin 1a and neuronal Sec1 (nSec1) form an evolutionarily conserved heterodimer that is essential for vesicle trafficking and membrane fusion. The crystal structure of the nSec1-syntaxin 1a complex, determined at 2.6 A resolution, reveals that major conformational rearrangements occur in syntaxin relative to both the core SNARE complex and isolated syntaxin. We identify regions of the two proteins that seem to determine the binding specificity of particular Sec1 proteins for syntaxin isoforms, which is likely to be important for the fidelity of membrane trafficking. The structure also indicates mechanisms that might couple the action of upstream effector proteins to conformational changes in syntaxin 1a and nSec1 that lead to core complex formation and membrane fusion.

About this Structure

1DN1 is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex., Misura KM, Scheller RH, Weis WI, Nature. 2000 Mar 23;404(6776):355-62. PMID:10746715

Page seeded by OCA on Thu Mar 20 10:41:07 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dn1"
Personal tools