This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Fibronectin
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin 4-5FnI fragment [[1fbr]]]] | [[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin 4-5FnI fragment [[1fbr]]]] | ||
| - | {{STRUCTURE_3m7p| PDB=3m7p | SIZE=400| SCENE= |right|CAPTION=Human fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions [[3m7p]] }} | + | {{STRUCTURE_3m7p| PDB=3m7p | SIZE=400| SCENE= |right|CAPTION=Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) [[3m7p]] }} |
| Line 37: | Line 37: | ||
[[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, ''i.e.'' the crystal structure of human Fibronectin 4-5FnI fragment ([[1fbr]]). | [[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, ''i.e.'' the crystal structure of human Fibronectin 4-5FnI fragment ([[1fbr]]). | ||
| - | |||
| - | {{TOC limit|limit=2}} | ||
== 3D Structures of Fibronectin == | == 3D Structures of Fibronectin == | ||
| Line 67: | Line 65: | ||
[[2fn2]] – hFn 2FnII – NMR | [[2fn2]] – hFn 2FnII – NMR | ||
| - | |||
=== Fn module FnIII === | === Fn module FnIII === | ||
| Line 83: | Line 80: | ||
[[1mfn]], [[2mfn]] – Fn 9-10FnIII – mouse - NMR<br /> | [[1mfn]], [[2mfn]] – Fn 9-10FnIII – mouse - NMR<br /> | ||
[[2vmg]], [[2vmi]] - Fn FnIII carbohydrate-binding domain – ''Clostridium perfringens'' | [[2vmg]], [[2vmi]] - Fn FnIII carbohydrate-binding domain – ''Clostridium perfringens'' | ||
| - | |||
=== Fn module FnI+FnII === | === Fn module FnI+FnII === | ||
Revision as of 08:30, 18 August 2014
Fibronectin (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, i.e. the crystal structure of human Fibronectin 4-5FnI fragment (1fbr).
Contents |
3D Structures of Fibronectin
Updated on 18-August-2014
Fn module FnI
3m7p – hFn GBD – human
1e8b, 1e88, 1qo6 - hFn GBD – NMR
3gxe, 3ejh – hFn 8-9FnI+collagen alpha-1
1fbr - hFn 4-5FnI - NMR
2rky, 2rl0 – hFn 4-5FnI+Fn binding peptide
2rkz, 3cal, 3zrz - hFn 2-3FnI+Fn binding peptide
2cg6, 2cg7 - hFn 2-3FnI
2cku - hFn 2-3FnI – NMR
1o9a - hFn 1-2FnI+B3 from FNBB – NMR
2ec3 – hFn 11FnI – NMR
3r8q – hFn 12-14FnI
1qgb – hFn FnI N-terminal - NMR
2ck2 – hFn (mutant) core swapped
1j8k – hFn extra domain 2 – NMR
1fnh – hFn heparin and integrin binding domains
2qbw, 3ch8 – hFn-PDZ fusion
4gh7 – hFn residues 1173-1448 + Neutrophil gelatinase-associated lipocalin
Fn module FnII
2fn2 – hFn 2FnII – NMR
Fn module FnIII
1q38, 1x3d, 1x4x, 1x5x - hFn FnIII – NMR
2h41, 2h45 – hFn 2FnIII – NMR
1oww - hFn 1FnIII – NMR
2ha1 - hFn 1-2FnIII – NMR
2crm - hFn 4FnIII – NMR
2crz - hFn 5FnIII – NMR
1fna, 1ttf, 1ttg – hFn 10FnIII
2ocf - hFn 10FnIII+estrogen receptor ligand-binding domain
1fnf – hFn 7-10FnIII
2fnb – hFn FnIII ed-b domain – NMR
1mfn, 2mfn – Fn 9-10FnIII – mouse - NMR
2vmg, 2vmi - Fn FnIII carbohydrate-binding domain – Clostridium perfringens
Fn module FnI+FnII
3mql – hFn 6FnI+2FnII+7FnI
