Histone deacetylase
From Proteopedia
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* [[Understanding of the Recruitment of HDACs by MEF2, Based on Their Structure]]<br /> | * [[Understanding of the Recruitment of HDACs by MEF2, Based on Their Structure]]<br /> | ||
* [[Transcription and RNA Processing]]. | * [[Transcription and RNA Processing]]. | ||
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== 3D Structures of histone deacetylase == | == 3D Structures of histone deacetylase == | ||
Revision as of 10:44, 18 August 2014
Histone deacetylase (HDAC) catalyzes the removal of acetyl group from ε-N-acetyl lysine in histones. HDAC contains Zn. DNA expression is regulated by acetylation and de-acetylation. HDAC are classified according to their domain organization to 4 classes. SAHA is a common inhibitor of HDAC. For additional details see
- Understanding of the Recruitment of HDACs by MEF2, Based on Their Structure
- Transcription and RNA Processing.
Contents |
3D Structures of histone deacetylase
Updated on 18-August-2014
HDAC class I
HDAC1
4bkx – hHDAC1 + MTA1 – human
3hgq, 3hgt – hHDAC1 subunit 3
HDAC2
3max – hHDAC2 + amide derivative
4lxz – hHDAC2 core domain + SAHA
4ly1 – hHDAC2 core domain + inhibitor
HDAC3
4a69 – hHDAC3 + nuclear receptor corepressor 2 + inositol tetraphosphate
HDAC8
3ew8, 3ezp, 3ezt, 3f06 – hHDAC8 (mutant)
3sff, 3sfh – hHDAC8 + inhibitor
1t64, 3f0r – hHDAC8 + trichostatin A
1t67, 1w22, 1vkg, 3f07 - hHDAC8 + amide derivative
1t69 - hHDAC8 + SAHA
3mz3 - hHDAC8 (Co) + amide derivative
3mz7 - hHDAC8 (Co) (mutant) + amide derivative
3mz4 - hHDAC8 (Mn) (mutant) + amide derivative
3mz6 - hHDAC8 (Fe) (mutant) + amide derivative
2v5x - hHDAC8 (mutant) + octanediamide derivative
2v5w – hHDAC8 + tripeptide
3ewf - hHDAC8 (mutant) + polypeptide
3rqd - hHDAC8 + largazole
4bz5 – SmHDAC8 – Schistosoma mansoni
4bz7, 4bz8, 4bz9 – SmHDAC8 + inhibitor
4bz6 – SmHDAC8 + SAHA
HDAC class IIA
HDAC4
2h8n – hHDAC4 N terminal
2o94 - hHDAC4 N terminal (mutant)
2vqw - hHDAC4 catalytic domain (mutant)
2vqj, 2vqm, 4cbt – hHDAC4 catalytic domain + inhibitor
2vqo, 2vqq, 2vqv, 4cby – hHDAC4 catalytic domain (mutant) + inhibitor
HDAC7
3c0y – hHDAC7 catalytic domain
3c0z - hHDAC7 catalytic domain + octanedioic acid hydroxyamide phenylamide
3c10 - hHDAC7 catalytic domain + trichostatin A
3znr, 3zns - hHDAC7 catalytic domain + inhibitor
HDAC9
1tqe – mHDAC9 + myocyte-specific enhancer factor + DNA – mouse
HDAC
4a6q, 4a90 - hHDAC subunit SAP18
2hde – hHDAC subunit SAP18 (mutant) – NMR
4a8x - hHDAC subunit SAP18 + RNA-binding protein + hook-like
2kdp – hHDAC subunit SAP30 – NMR
2ld7 – hHDAC subunit SAP30 +SIN3A PAH 3 domain – NMR
HDAC class IIB
HDAC6
3c5k – hHDAC6 zinc finger domain
3gv4 - hHDAC6 zinc finger domain + ubiquitin peptide
3phd - hHDAC6 + polyubiquitin
HDAC class III
Sir2
2hjh – yHDAC Sir2 - yeast
4iao – yHDAC Sir2 + Sir4
