Kdo-8-phosphate synthase
From Proteopedia
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[[4lu0]] – KPS – ''Pseudomonas aeruginosa''<br /> | [[4lu0]] – KPS – ''Pseudomonas aeruginosa''<br /> | ||
| - | + | ''Metallo Kdo8P binary complex'' | |
[[1fws]] – AaKPS + PEP + Cd<br /> | [[1fws]] – AaKPS + PEP + Cd<br /> | ||
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[[3tmq]] - BpKPS + arabinose-5-phosphate<br /> | [[3tmq]] - BpKPS + arabinose-5-phosphate<br /> | ||
| - | + | ''Metallo Kdo8P ternary complex'' | |
[[1fwt]] - AaKPS + erythrose-4-phosphate + PEP + Cd<br /> | [[1fwt]] - AaKPS + erythrose-4-phosphate + PEP + Cd<br /> | ||
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[[3t4c]], [[3tml]] - KPS – Burkholderia ambifaria | [[3t4c]], [[3tml]] - KPS – Burkholderia ambifaria | ||
| - | + | ''Non-metallo Kdo8P binary complex'' | |
[[2nxi]], [[1fwn]] - AaKPS + PEP<br /> | [[2nxi]], [[1fwn]] - AaKPS + PEP<br /> | ||
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[[1x6u]] - EcKPS + Kdo-8-P | [[1x6u]] - EcKPS + Kdo-8-P | ||
| - | + | ''Non-metallo Kdo8P ternary complex'' | |
| - | + | ||
[[1fxq]] - AaKPS + A5P + PEP<br /> | [[1fxq]] - AaKPS + A5P + PEP<br /> | ||
Revision as of 07:09, 19 August 2014
Kdo-8-phosphate synthase (KPS) catalyzes the formation of the phosphorylated rare sugar Kdo-8-phosphate (Kdo-8-P) from phosphoenolpyruvate (PEP) and D-arabinose-5-phosphate (A5P). KPS is a metal-requiring enzyme. Kdo-8-P is found in cell walls of higher plants and some green algae.
3D structures of Kdo-8-phosphate synthase
Metallo Kdo8P
1fxp - AaKPS + Cd – Aquifex aeolicus
1lrn, 1t99 - AaKPS (mutant) + Cd
2qkf – NmKPS + Na – Neisseria meningitides
3fyo - NmKPS (mutant) + Mn
3qpy, 3qpz, 3qq0, 3stc, 3ste, 3stf, 4jte, 4jtf, 4jtg, 4jth, 4jti, 4jtj, 4jtk, 4jtl - NmKPS (mutant) + Na
3sz8 – BpKPS-2 – Burkholderia pseudomallei
4lu0 – KPS – Pseudomonas aeruginosa
Metallo Kdo8P binary complex
1fws – AaKPS + PEP + Cd
3e0i - AaKPS + PEP + Cu
1lro, 1t96 - AaKPS (mutant) + PEP + Cd
1pck - AaKPS + PEP derivative + Cd
1pe1 - AaKPS + phosphoglyceric acid + Cd
2a21 - EcKPS + PEP + Zn - Escherichia coli
1jcx, 1pcw - AaKPS + inhibitor + Cd
1fy6 - AaKPS + A5P + Cd
3e12 - AaKPS + Kdo-8-P + Cu
3fyp - NmKPS (mutant) + PEP + Mn
3tmq - BpKPS + arabinose-5-phosphate
Metallo Kdo8P ternary complex
1fwt - AaKPS + erythrose-4-phosphate + PEP + Cd
1jcy - AaKPS + ribose-5-phosphate + PEP + Cd
1zha - AaKPS (mutant) + ribose-5-phosphate + PEP + Cd
1zji - AaKPS (mutant) + ribose-5-phosphate + phosphoglyceric acid + Cd
1fww - AaKPS + A5P + PEP + Cd
2a2i - AaKPS + A5P + PEP + Zn
1lrq, 1t8x - AaKPS (mutant) + A5P + PEP + Cd
3und - BpKPS + arabinose-5-phosphate + PEP
Non-metallo Kdo8P
1d9e, 1gg0, 1x8f – EcKPS
1fx6 - AaKPS
2nws, 2nx3 - AaKPS (mutant)
1o60 - KPS – Haemophilus influenza
3e9a - KPS – Vibrio cholera
3fs2 - KPS – Brucella melitensis
3qq1, 3stg - NmKPS (mutant)
3t4c, 3tml - KPS – Burkholderia ambifaria
Non-metallo Kdo8P binary complex
2nxi, 1fwn - AaKPS + PEP
2nwr, 2nxh - AaKPS (mutant) + PEP
1g7u, 1q3n - EcKPS + PEP
1phq, 1pl9 - EcKPS + PEP derivative
1phw - EcKPS + A5P derivative
1g7v - EcKPS + inhibitor
1x6u - EcKPS + Kdo-8-P
Non-metallo Kdo8P ternary complex
1fxq - AaKPS + A5P + PEP
2nx1, 2ef9 - AaKPS (mutant) + A5P + PEP
2nxg - AaKPS (mutant) + octanoic acid derivative + A5P + PEP
