Lactate Dehydrogenase

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__NOTOC__
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<StructureSection load='' size='450' side='right' scene='Lactate_Dehydrogenase/Cv/5' caption='Lactate dehydrogenase dimer complex with cofactor NAD and pyruvate (PDB code [[2fm3]])'>
<StructureSection load='' size='450' side='right' scene='Lactate_Dehydrogenase/Cv/5' caption='Lactate dehydrogenase dimer complex with cofactor NAD and pyruvate (PDB code [[2fm3]])'>
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The <scene name='Lactate_Dehydrogenase/Secondary/2'>secondary structure</scene> of LDH as shown here is comprised of 40% alpha helices and 23% beta sheets<ref name="2nd">http://www.cheric.org/ippage/e/ipdata/2004/05/file/e200405-701.pdf </ref>. The SCOP data classifies this form of lactate dehydrogenase as mixed beta-alpha-beta, with mainly parallel beta sheets.
The <scene name='Lactate_Dehydrogenase/Secondary/2'>secondary structure</scene> of LDH as shown here is comprised of 40% alpha helices and 23% beta sheets<ref name="2nd">http://www.cheric.org/ippage/e/ipdata/2004/05/file/e200405-701.pdf </ref>. The SCOP data classifies this form of lactate dehydrogenase as mixed beta-alpha-beta, with mainly parallel beta sheets.
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===Catalysis===
===Catalysis===
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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===L-LDH===
[[2e37]], [[2v6m]] – TtL-LDH – ''Thermus thermophilus''<BR />
[[2e37]], [[2v6m]] – TtL-LDH – ''Thermus thermophilus''<BR />
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[[3ks0]] - LDH residues 86-180 + flavocytochrome b2 heme domain + FAB B2B4
[[3ks0]] - LDH residues 86-180 + flavocytochrome b2 heme domain + FAB B2B4
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===L-LDH binary complex===
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''L-LDH binary complex''
[[2ydn]], [[4b7u]] – PfL-LDH + bicine<BR />
[[2ydn]], [[4b7u]] – PfL-LDH + bicine<BR />
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[[4i8x]], [[4i9h]], [[4i9n]], [[4i9u]] – rLDH A chain + pyridine derivative - rabbit<br />
[[4i8x]], [[4i9h]], [[4i9n]], [[4i9u]] – rLDH A chain + pyridine derivative - rabbit<br />
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===L-LDH ternary complex with inhibitor===
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''L-LDH ternary complex with inhibitor''
[[1u5c]] - PfL-LDH + inhibitor + NAD<BR />
[[1u5c]] - PfL-LDH + inhibitor + NAD<BR />
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[[9ldb]], [[9ldt]] - pL-LDH + oxamate + NAD – pig
[[9ldb]], [[9ldt]] - pL-LDH + oxamate + NAD – pig
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===L-LDH ternary complex with reactants===
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''L-LDH ternary complex with reactants''
[[1sow]], [[1pzh]] - TgL-LDH + oxalate + NAD<BR />
[[1sow]], [[1pzh]] - TgL-LDH + oxalate + NAD<BR />

Revision as of 07:19, 19 August 2014

Lactate dehydrogenase dimer complex with cofactor NAD and pyruvate (PDB code 2fm3)

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Contents

3D structures of lactate dehydrogenase

Updated on 19-August-2014

L-LDH

2e37, 2v6m – TtL-LDH – Thermus thermophilus
2xxe, 3zzn, 4a73– TtL-LDH (mutant)
2x8l, 1ceq – PfL-LDH – Plasmodium falciparum
2zqy, 2zqz, 1llc – LcL-LDH – Lactobacillus casei
3vku - LcL-LDH (mutant)
3d0o - SaL-LDH – Staphylococcus aureus
2v65 - L-LDH A chain – Champsocephalus gunnari
2v6b – L-LDH – Deinococcus radiodurans
2frm – CpLDH – Cryptosporidium parvum
1sov, 1pze - TgL-LDH – Toxoplasma gondii
1v6a – L-LDH A chain – Cyprinus carpio
1y6j – L-LDH – Clostridium thermocellum
1ldb - GsL-LDH – Geobacillus stearothermophilus
1ldm, 6ldh, 8ldh – sdM4-LDH – spiny dogfish
2ldx – C4-LDH - mouse
4m1q - BseL-LDH – Bacillus selenitireducens
3pqe – BsL-LDH (mutant) – Bacillus subtilis
4lmr, 4ln1 - LDH – Bacillus cereus
3vpg – TcLDH – Thermus caldophilus

L-LDH from yeast (cytochrome b2)

1kbj - LDH FMN-binding domain
1sze, 1lco, 2oz0 - LDH FMN-binding domain (mutant)
1kbi - LDH FMN-binding domain + pyruvate
1szf, 1ldc - LDH FMN-binding domain (mutant) + pyruvate
1szg - LDH FMN-binding domain + sulfo-FMN
3ks0 - LDH residues 86-180 + flavocytochrome b2 heme domain + FAB B2B4

L-LDH binary complex

2ydn, 4b7u – PfL-LDH + bicine
1cet - PfL-LDH + chloroquine
1t2c - PfL-LDH + NAD
3zh2 - PfL-LDH + DNA aptamer
1ez4 - L-LDH + NAD – Lactobacillus pentosus
1lld, 2ldb - GsL-LDH + NAD
2a92 – PvL-LDH + NAD – Plasmodium vivax
2a94, 2aa3 - PvL-LDH + NAD-analog
1u4o, 1u4s, 1u5a, 1xiv – PfL-LDH + inhibitor
2xxb – TtL-LDH (mutant) + AMP
3pqf – BsL-LDH (mutant) + NAD
3vkv - LcLDH + fructose-bisphosphate
3vpf – LcLDH (mutant) + pyruvate
4aj1, 4aj2, 4aj4, 4aje, 4ajh, 4aji, 4ajj, 4ajk, 4ajl, 4ajn, 4ajo, 4al4 – LDH α chain + inhibitor – rat
4ajp, 4m49 – hLDH α chain + inhibitor - human
4i8x, 4i9h, 4i9n, 4i9u – rLDH A chain + pyridine derivative - rabbit

L-LDH ternary complex with inhibitor

1u5c - PfL-LDH + inhibitor + NAD
1t24, 1t25, 1t26 - PfL-LDH + azole derivative + NAD
1t2e - PfL-LDH (mutant) + oxamate + NAD
1ldg - PfL-LDH + oxamate + NAD
2xxj – TtL-LDH (mutant) + oxamate + NAD
2v7p - TtL-LDH + oxamate + NAD
3om9, 3czm – TgL-LDH + OXQ + NAD
3h3f – rL-LDH A chain + oxamate + NAD
2fnz - CpLDH + oxamate + NAD
1t2f - hL-LDH B chain + azole derivative + NAD
1i0z - hL-LDH H chain + oxamate + NAD
1i10 - hL-LDH M chain + oxamate + NAD
4jnk - hL-LDH A chain + inhibitor + lactate + NAD
3vph - TcLDH + oxamate + NAD + fructose diphosphate
1oc4 – L-LDH + oxamate + NAD – Plasmodium berghei
1a5z - L-LDH + oxamate + NAD – Thermotoga maritima
1lth - L-LDH + oxamate + NAD – Bifidobacterium longum
1ldn - GsL-LDH + oxamate + NAD
9ldb, 9ldt - pL-LDH + oxamate + NAD – pig

L-LDH ternary complex with reactants

1sow, 1pzh - TgL-LDH + oxalate + NAD
1t2d - PfL-LDH + oxalate + NAD
1pzf - TgL-LDH + oxalate + NAD-analog
1pzg - TgL-LDH + sulfate + NAD-analog
3h3j – SaL-LDH (mutant) + pyruvate + NAD
3d4p - SaL-LDH + pyruvate + NAD
2fn7 - CpLDH + lactate + NAD
2ewd - CpLDH + pyruvate + NAD-analog
2fm3 - CpLDH + pyruvate + NAD
5ldh - pLDH + citrate + NAD-analog
3ldh - sdLDH + pyruvate + NAD
3pqd - BsLDH + fructose-bisphosphate + NAD

D-LDH

3kb6 – D-LDH + lactate + NAD – Aquifex aeolicus
1j49 – LdD-LDH + sulfate + NAD – Lactobacillus delbrueckii
1j4a - LdD-LDH + sulfate
1f0x – EcD-LDH + FAD – Escherichia coli
2dld - D-LDH + oxamate + NAD – Lactobacillus helveticus

L-LDH II

1x0a, 1vbi – TtL-LDH II

L-Lactate/malate dehydrogenase

1hye, 1hyg – L-LDH/MDH – Methanocaldococcus jannaschi
2g8y - EcL-LDH/MDH

Additional Information

For additional information, see Carbohydrate Metabolism

Reference

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