Lactoperoxidase
From Proteopedia
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | + | ===Lactoperoxidase binary complex=== | |
[[2pt3]] - bPLO + phosphate - bovine<br /> | [[2pt3]] - bPLO + phosphate - bovine<br /> | ||
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[[4ig5]] – gLPO + methimazole<br /> | [[4ig5]] – gLPO + methimazole<br /> | ||
| - | + | ===Lactoperoxidase ternary complex=== | |
[[2gj1]] – bLPO + carbonate + nitrate <br /> | [[2gj1]] – bLPO + carbonate + nitrate <br /> | ||
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[[2ikc]] – sLPO + carbonate + formate – sheep | [[2ikc]] – sLPO + carbonate + formate – sheep | ||
| - | + | ===Lactoperoxidase quaternary complex=== | |
[[3gcj]], [[2qpk]] - bPLO + salicylhydroxamic acid + SCN + I<br /> | [[3gcj]], [[2qpk]] - bPLO + salicylhydroxamic acid + SCN + I<br /> | ||
Revision as of 07:23, 19 August 2014
Lactoperoxidase (LPO) catalyzes the oxidation of thiocyanate, bromide and iodide using hydrogen peroxide. The short-lived oxidized intermediates of the reaction serve as potent bactericidal agents. LPO is used as an antimicrobial agent in milk and its products, in cosmetics, toothpaste and ophthalmic solutions. LPO is the second most abundant enzyme in milk. Heme is the cofactor of LPO. LPO contains a strongly-chelated calcium ion.
Contents |
3D structures of lactoperoxidase
Updated on 19-August-2014
Lactoperoxidase binary complex
2pt3 - bPLO + phosphate - bovine
2nqx – bPLO + I
2r5l – gLPO + I – goat
3nak – gLPO + formate
4ig5 – gLPO + methimazole
Lactoperoxidase ternary complex
2gj1 – bLPO + carbonate + nitrate
2ips, 3eri, 3gc1 – bLPO + SCN + I
2qrb – bLPO + SCN + Cl
3bxi – bLPO + SCN + nitrate
4pnx - bPLO + bromomethane + I
2pum – bPLO + catechol + I
2gj1 – bLPO + carbonate + nitrate
3krq – bLPO + amino-triazole + I
2z5z – wbPLO + F + I – water buffalo
2o86 – wbPLO + nitrate + I
3erh - wbLPO + SCN + I
2ojv – gPLO + CN + I
3n8f - gLPO + SCN + nitrate
3niu – gLPO + diethylene glycol + phosphate
3rke - gPLO + inhibitor + I
2ikc – sLPO + carbonate + formate – sheep
Lactoperoxidase quaternary complex
3gcj, 2qpk - bPLO + salicylhydroxamic acid + SCN + I
3gck - bPLO + benzylhydroxamic acid + SCN + I
3uba, 4gm7 - bPLO + hydroxycinnamic acid + SCN + I
3gcl, 2qqt - bPLO + aspirin + SCN + I
3i6n - bPLO + isoniazid + SCN + I
4ksz - bPLO + cystein + SCN + I
3nyh - bPLO + Br + Cl + SCN + I
3ogw - bPLO + indomethacin + SCN + I
3py4, 4gn6 - bPLO + paracetamol + SCN + I
3q9k - bPLO + phenyliso-SCN + SCN + I
3ql6 - bPLO + nitro-phenoxymethanesulfonanilide+ SCN + I
3s4f, 4njb, 4nt3 - bPLO + pyridine derivative + SCN + I
3r4x, 3tuw - bPLO + pyrazine derivative + SCN + I
3r5o - bPLO + methoxyphenol + SCN + I
3tgy - bPLO + ascorbate + SCN + I
3v6q - bPLO + CO + SCN + I
2gjm - wbPLO + carbonate + SCN + I
3faq – wbLPO + CN + SCN + I
3fnl - wbPLO + salicylhydroxamic acid + SCN + I
2e9e – gPLO + nitrate + carbonate + SCN + CN
2efb – gPLO + phosphate + carbonate + SCN + CN
3qf1 - gPLO + piperazine + SCN + I
4ljj - gPLO + acrylonitrile + SCN + I
4msf, 4oek - gPLO + phenol derivative+ SCN + I
2eha – gPLO + formate + carbonate + SCN
3r55, 4n7a - gPLO + pyrazine derivative + SCN + I
3sxv - gPLO + amitrole + SCN + I
3r5q - sPLO +tetrahydrofuran + SCN + I
Proteopedia Page Contributors and Editors (what is this?)
Joel L. Sussman, Michal Harel, Alexander Berchansky, Jaime Prilusky
