Mitogen-activated protein kinase kinase kinase
From Proteopedia
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[[Mitogen-activated protein kinase kinase kinase]] (MAP3K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP3K is part of the MAPK cascade which consists also of [[Mitogen-activated protein kinase|MAPK]] and [[Mitogen-activated protein kinase kinase|MAP2K]] which are activated by phosphorylation. MAP3K activates [[Mitogen-activated protein kinase kinase|MAP2K]]. The images on the left and right correspond to one representative MAP3K structure, ''i.e.'' the human MAP3K5 ([[2clq]]). | [[Mitogen-activated protein kinase kinase kinase]] (MAP3K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP3K is part of the MAPK cascade which consists also of [[Mitogen-activated protein kinase|MAPK]] and [[Mitogen-activated protein kinase kinase|MAP2K]] which are activated by phosphorylation. MAP3K activates [[Mitogen-activated protein kinase kinase|MAP2K]]. The images on the left and right correspond to one representative MAP3K structure, ''i.e.'' the human MAP3K5 ([[2clq]]). | ||
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== 3D Structures of Mitogen-activated protein kinase kinase == | == 3D Structures of Mitogen-activated protein kinase kinase == | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | == MAP3K1 == | + | === MAP3K1 === |
[[1uti]] - MAP3K1+GRB2-related adaptor protein 2 - mouse | [[1uti]] - MAP3K1+GRB2-related adaptor protein 2 - mouse | ||
| - | ==MAP3K2 == | + | ===MAP3K2 === |
[[2cu1]] - hMAP3K2 PB1 domain (mutant) - human - NMR<br /> | [[2cu1]] - hMAP3K2 PB1 domain (mutant) - human - NMR<br /> | ||
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[[2npt]] - hMAP3K2 PHOX domain + hMAP2K5 PHOX domain | [[2npt]] - hMAP3K2 PHOX domain + hMAP2K5 PHOX domain | ||
| - | ==MAP3K3 == | + | ===MAP3K3 === |
[[2c60]] – hMAP3K3 PHOX domain<br /> | [[2c60]] – hMAP3K3 PHOX domain<br /> | ||
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[[2pph]] - hMAP3K3 PB1 domain - NMR | [[2pph]] - hMAP3K3 PB1 domain - NMR | ||
| - | ==MAP3K5 == | + | ===MAP3K5 === |
[[2clq]] – hMAP3K5<br /> | [[2clq]] – hMAP3K5<br /> | ||
[[4bf2]], [[4bhn]], [[4bib]], [[4bic]], [[4bid]], [[4bie]] - hMAP3K5 (mutant) + inhibitor<br /> | [[4bf2]], [[4bhn]], [[4bib]], [[4bic]], [[4bid]], [[4bie]] - hMAP3K5 (mutant) + inhibitor<br /> | ||
| - | ==MAP3K7== | + | ===MAP3K7=== |
[[2eva]] – hMAP3K7/MAP3K7-interacting protein | [[2eva]] – hMAP3K7/MAP3K7-interacting protein | ||
| - | ==MAP3K9 == | + | ===MAP3K9 === |
[[3dtc]] - hMAP3K9 (mutant) + inhibitor | [[3dtc]] - hMAP3K9 (mutant) + inhibitor | ||
| - | ==MAP3K10 == | + | ===MAP3K10 === |
[[2rf0]] - hMAP3K10 SH3 domain - NMR | [[2rf0]] - hMAP3K10 SH3 domain - NMR | ||
Revision as of 08:37, 19 August 2014
Mitogen-activated protein kinase kinase kinase (MAP3K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP3K is part of the MAPK cascade which consists also of MAPK and MAP2K which are activated by phosphorylation. MAP3K activates MAP2K. The images on the left and right correspond to one representative MAP3K structure, i.e. the human MAP3K5 (2clq).
Contents |
3D Structures of Mitogen-activated protein kinase kinase
Updated on 19-August-2014
MAP3K1
1uti - MAP3K1+GRB2-related adaptor protein 2 - mouse
MAP3K2
2cu1 - hMAP3K2 PB1 domain (mutant) - human - NMR
2o2v, 1p38 – hMAP3K2+hMAP3K5 - human
2npt - hMAP3K2 PHOX domain + hMAP2K5 PHOX domain
MAP3K3
2c60 – hMAP3K3 PHOX domain
2jrh - hMAP3K3 PB1 domain
2pph - hMAP3K3 PB1 domain - NMR
MAP3K5
2clq – hMAP3K5
4bf2, 4bhn, 4bib, 4bic, 4bid, 4bie - hMAP3K5 (mutant) + inhibitor
MAP3K7
2eva – hMAP3K7/MAP3K7-interacting protein
MAP3K9
3dtc - hMAP3K9 (mutant) + inhibitor
MAP3K10
2rf0 - hMAP3K10 SH3 domain - NMR
MAP3K14
4dn5 - hMAP3K14 (mutant) + ATP-γ-S
4idt, 4idv - hMAP3K14 + inhibitor
