Pantothenate kinase
From Proteopedia
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{{STRUCTURE_2f9w| PDB=2f9w | SIZE=400| SCENE= |right|CAPTION=Pantothenate kinase III dimer complex with pantothenate, glycerol and ethane diol, [[2f9w]] }} | {{STRUCTURE_2f9w| PDB=2f9w | SIZE=400| SCENE= |right|CAPTION=Pantothenate kinase III dimer complex with pantothenate, glycerol and ethane diol, [[2f9w]] }} | ||
| - | '''Pantothenate kinase''' (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis. PanK is regulated by feedback inhibition by CoA and its thioesters. Three types of PanK are known. PanK I found in bacteria; PanK II found mostly in eukaryotes; PanK III found in bacteria and known as CoaX. | + | '''Pantothenate kinase''' (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis. PanK is regulated by feedback inhibition by CoA and its thioesters. Three types of PanK are known. '''PanK I''' found in bacteria; '''PanK II''' found mostly in eukaryotes; '''PanK III''' found in bacteria and known as CoaX. |
==3D structures of pantothenate kinase== | ==3D structures of pantothenate kinase== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| + | ===PanK I=== | ||
[[1esm]] – EcPanK + CoA – ''Escherichia coli''<br /> | [[1esm]] – EcPanK + CoA – ''Escherichia coli''<br /> | ||
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[[3tqc]] - PanK – ''Coxiella burnetii'' | [[3tqc]] - PanK – ''Coxiella burnetii'' | ||
| - | + | ''PanK I binary complex'' | |
[[2ges]], [[2get]], [[2zs7]], [[2geu]], [[2gev]] - MtPanK + CoA derivative – ''Mycobacterium tuberculosis''<br /> | [[2ges]], [[2get]], [[2zs7]], [[2geu]], [[2gev]] - MtPanK + CoA derivative – ''Mycobacterium tuberculosis''<br /> | ||
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[[4bfy]], [[4bfz]] - MtPanK + biaryl inhibitor<br /> | [[4bfy]], [[4bfz]] - MtPanK + biaryl inhibitor<br /> | ||
| - | + | ''PanK I ternary complex'' | |
[[2zs9]] - MtPanK + ADP + PAU<br /> | [[2zs9]] - MtPanK + ADP + PAU<br /> | ||
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[[4gi7]] – KpPanK + ADP + pantothenate analog<br /> | [[4gi7]] – KpPanK + ADP + pantothenate analog<br /> | ||
| - | ==PanK II== | + | ===PanK II=== |
[[2ews]] - SaPanK + ANP – ''Staphylococcus aureus''<br /> | [[2ews]] - SaPanK + ANP – ''Staphylococcus aureus''<br /> | ||
[[4nb4]] - SaPanK + ADP + pantothenamide<br /> | [[4nb4]] - SaPanK + ADP + pantothenamide<br /> | ||
| - | ==PanK III== | + | ===PanK III=== |
[[2gtd]] - TmPanK – ''Thermotoga maritima''<br /> | [[2gtd]] - TmPanK – ''Thermotoga maritima''<br /> | ||
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[[4o8k]] - BtPanK – ''Burkholderia thailandensis''<br /> | [[4o8k]] - BtPanK – ''Burkholderia thailandensis''<br /> | ||
| - | + | ''PanK III binary complex'' | |
[[2f9w]] - PaPanK + PAU<br /> | [[2f9w]] - PaPanK + PAU<br /> | ||
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[[3bf3]] - TmPanK + PPT<BR /> | [[3bf3]] - TmPanK + PPT<BR /> | ||
| - | + | ''PanK III ternary complex'' | |
[[3bf1]] - TmPanK + ADP + PAU<br /> | [[3bf1]] - TmPanK + ADP + PAU<br /> | ||
[[4o5f]] - BtPanK + ADP + PAU <br /> | [[4o5f]] - BtPanK + ADP + PAU <br /> | ||
| - | ==Human PanK== | + | ===Human PanK=== |
[[2i7n]], [[3smp]] - hPanK 1 α + CoA - human<br /> | [[2i7n]], [[3smp]] - hPanK 1 α + CoA - human<br /> | ||
Revision as of 09:47, 19 August 2014
Pantothenate kinase (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis. PanK is regulated by feedback inhibition by CoA and its thioesters. Three types of PanK are known. PanK I found in bacteria; PanK II found mostly in eukaryotes; PanK III found in bacteria and known as CoaX.
Contents |
3D structures of pantothenate kinase
Updated on 19-August-2014
PanK I
1esm – EcPanK + CoA – Escherichia coli
1esn - EcPanK + ANP
1sq5 - EcPanK + ADP + PAU
3tqc - PanK – Coxiella burnetii
PanK I binary complex
2ges, 2get, 2zs7, 2geu, 2gev - MtPanK + CoA derivative – Mycobacterium tuberculosis
2zs8, 2zsb - MtPanK + ADP
3af1 - MtPanK + GDP
3af2 - MtPanK + AMPPCP
3af4 - MtPanK + GMPPCP
2zsd - MtPanK + CoA
3avo - MtPanK + PAU
3avp, 3avq - MtPanK + PAU derivative
4bfs, 4bft, 4bfu, 4bfv, 4bfw, 4bfx - MtPanK + triazole inhibitor
4bfy, 4bfz - MtPanK + biaryl inhibitor
PanK I ternary complex
2zs9 - MtPanK + ADP + PAU
2zse - MtPanK + AMPPCP + PAU
3af3 - MtPanK + GMPPCP + PAU
2zsf - MtPanK + ADP + ATP
2zsa - MtPanK + ADP + PPT
3aez - MtPanK + GDP + PPT
3af0 - MtPanK + GDP + PAU
4f7w, 4ne2 – KpPanK + ADP + pantothenamide derivative – Klebsiella pneumonia
4gi7 – KpPanK + ADP + pantothenate analog
PanK II
2ews - SaPanK + ANP – Staphylococcus aureus
4nb4 - SaPanK + ADP + pantothenamide
PanK III
2gtd - TmPanK – Thermotoga maritima
2f9t – PaPanK – Pseudomonas aeruginosa
2h3g - PanK – Bacillus anthracis
3djc - PanK – Legionella pneumophila
4o8k - BtPanK – Burkholderia thailandensis
PanK III binary complex
2f9w - PaPanK + PAU
3bex - TmPanK + PAU
3bf3 - TmPanK + PPT
PanK III ternary complex
3bf1 - TmPanK + ADP + PAU
4o5f - BtPanK + ADP + PAU
Human PanK
2i7n, 3smp - hPanK 1 α + CoA - human
2i7p, 3mk6 - hPanK 3 + CoA
3sms – hPanK 3 + PAU analog
