Phosphoenolpyruvate carboxykinase
From Proteopedia
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{{STRUCTURE_2olr| PDB=2olr | SIZE=350| SCENE= |right|CAPTION=ATP-driven E. coli PEPCK complex with ATP (stick model), CO2 and Mg+2 ion (green) [[2olr]] }} | {{STRUCTURE_2olr| PDB=2olr | SIZE=350| SCENE= |right|CAPTION=ATP-driven E. coli PEPCK complex with ATP (stick model), CO2 and Mg+2 ion (green) [[2olr]] }} | ||
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'''Phosphoenolpyruvate carboxykinase''' (PEPCK) catalyzes the conversion of oxaloacetate to phosphoenolpyruvate (PEP) and CO2. PEPCK is part of the gluconeogenesis pathway. There are 3 types of PEPCK distinguished by the energy source of the reaction which can be GTP, ATP or diphosphate. | '''Phosphoenolpyruvate carboxykinase''' (PEPCK) catalyzes the conversion of oxaloacetate to phosphoenolpyruvate (PEP) and CO2. PEPCK is part of the gluconeogenesis pathway. There are 3 types of PEPCK distinguished by the energy source of the reaction which can be GTP, ATP or diphosphate. | ||
Revision as of 06:18, 20 August 2014
Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the conversion of oxaloacetate to phosphoenolpyruvate (PEP) and CO2. PEPCK is part of the gluconeogenesis pathway. There are 3 types of PEPCK distinguished by the energy source of the reaction which can be GTP, ATP or diphosphate.
3D Structures of PEPCK
Updated on 20-August-2014
PEPCK ATP driven
1oen, 1fiy – EcPEPCK - Escherichia coli
1ayl – EcPEPCK + ATP + oxalate + Mg
1aq2 – EcPEPCK + ATP + pyruvate + Mg + Mn
2py7 – EcPEPCK (mutant) + ATP + Mg + Mn
2olq – EcPEPCK + ATP + CO2 + Mg + Mn
2pxz – EcPEPCK + ATP + CO2 + oxaloacetate + Mg + Mn
2olr – EcPEPCK + ATP + CO2 + Mg
1os1 – EcPEPCK + ATP + pyruvate + Mg + Ca
1k3c – EcPEPCK + ADP + pyruvate + Mg + AlF3
1k3d – EcPEPCK + ADP + Mg + AlF3
1j3b – TtPEPCK – Thermus thermophilus
1yvy – AnsPEPCK – Anaerobiospirillum succiniciproducens
1ytm – AnsPEPCK + ATP + oxalate + Mg + Mn
1xkv, 2pc9 – TtPEPCK + ATP
PEPCK GTP driven
1khb – EcPEPCK + GTP analog + Mg
1khe – EcPEPCK + GTP analog + Mn
1khf – EcPEPCK + PEP + Mn
1khg – EcPEPCK + Mn
1m51, 1nhx – EcPEPCK + inhibitor + Mn
2faf – cPEPCK + Mn - chicken
2fah – cPEPCK + GDP + Mn
2qzy – cPEPCK + PEP + Mn
2gmv – hPEPCK + inhibitor + PEP + Mn - human
2qew – rPEPCK + Mn - rat
2qey – rPEPCK + GTP + Mn
2qf1 – rPEPCK + oxaloacetate + Mn
2rk7 – rPEPCK + oxalate + Mn
4gnm, 4gnq - rPEPCK + oxalate + GTP + Mn
4gmw, 4gnl, 4gnp – rPEPCK + PEP + GDP + Mn
3dt2, 3dt4, 4gmu – rPEPCK + GTP + oxalate + Mn
3mof – rPEPCK (mutant) + GTP + oxalate + Mn
3dt7, 4gmm, 4gmz, 4gno – rPEPCK + GTP + sulfopyruvate + Mn
3moe – rPEPCK (mutant) + GTP + sulfopyruvate + Mn
3dtb – rPEPCK + GTP + phosphoglycolate + Mn
3moh – rPEPCK (mutant) + GDP + phosphoglycolate + Mn
2rk8, 2rka, 2rkd, 2rke – rPEPCK + inhibitor + Mn
2qf2 – rPEPCK + GDP + oxaloacetate + Mn
2zci – PEPCK – Corynebacterium glutamicum
1ygg – AsPEPCK – Actinobacillus succinogenes
1ylh – AsPEPCK + pyruvate + Mn
1ii2 – PEPCK – Trypanosoma cruzi
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
