Pyruvate dehydrogenase kinase

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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'''PDK isozyme 1'''
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===PDK isozyme 1===
[[2q8f ]]– hPDK1 – human<br />
[[2q8f ]]– hPDK1 – human<br />
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[[2q8h]] – hPDK1 + dichloro-acetic acid
[[2q8h]] – hPDK1 + dichloro-acetic acid
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'''PDK isozyme 2'''
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===PDK isozyme 2===
[[1jm6]] – PDK2 + ADP – rat<br />
[[1jm6]] – PDK2 + ADP – rat<br />
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[[3crk]], [[3crl]] – hPDK2 + acetyltransferase component of pyruvate dehydrogenase complex
[[3crk]], [[3crl]] – hPDK2 + acetyltransferase component of pyruvate dehydrogenase complex
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'''PDK isozyme 3'''
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===PDK isozyme 3===
[[1y8n]], [[1y8o]], [[1y8p]], [[2pnr]] – hPDK3 + acetyltransferase component of pyruvate dehydrogenase complex <br />
[[1y8n]], [[1y8o]], [[1y8p]], [[2pnr]] – hPDK3 + acetyltransferase component of pyruvate dehydrogenase complex <br />
[[2q8i]] – hPDK3 + radicicol
[[2q8i]] – hPDK3 + radicicol
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'''PDK isozyme 4'''
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===PDK isozyme 4===
[[2e0a]] – hPDK4 + AMPPNP<br />
[[2e0a]] – hPDK4 + AMPPNP<br />

Revision as of 07:52, 20 August 2014

Template:STRUCTURE 1jm6

Pyruvate dehydrogenase kinase (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites.

Contents

3D structures of pyruvate dehydrogenase kinase

Updated on 20-August-2014

PDK isozyme 1

2q8f – hPDK1 – human
2q8g – hPDK1 + drug
2q8h – hPDK1 + dichloro-acetic acid

PDK isozyme 2

1jm6 – PDK2 + ADP – rat
2btz – hPDK2
2bu2 – hPDK2 + benzonitrile derivative + ATP
2bu5 - hPDK2 + benzonitrile derivative
2bu6 - hPDK2 + propanamide derivative
2bu7 - hPDK2 + acetamide derivative
2bu8 - hPDK2 + dichloro-acetic acid + ADP
4mp2, 4mp7, 4mpc, 4mpe, 4mpn – hPDK2 + inhibitor
3crk, 3crl – hPDK2 + acetyltransferase component of pyruvate dehydrogenase complex

PDK isozyme 3

1y8n, 1y8o, 1y8p, 2pnr – hPDK3 + acetyltransferase component of pyruvate dehydrogenase complex
2q8i – hPDK3 + radicicol

PDK isozyme 4

2e0a – hPDK4 + AMPPNP
2zkj, 3d2r – hPDK4 + ADP
2zdx, 2zdy – hPDK4 (mutant) + inhibitor

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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